HCSGD entry for IL7

1. General information

Official gene symbolIL7
Entrez ID3574
Gene full nameinterleukin 7
Other gene symbolsIL-7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002360T cell lineage commitmentIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005139Interleukin-7 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0006959Humoral immune responseTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008083Growth factor activityIEA ISSmolecular_function
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043086Negative regulation of catalytic activityIEAbiological_process
GO:0045453Bone resorptionISSbiological_process
GO:0045582Positive regulation of T cell differentiationISSbiological_process
GO:0046622Positive regulation of organ growthIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59793070550.06266752020.99999024730.4722777269

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0028618997
GSE13712_SHEARUp0.0683232538
GSE13712_STATICUp0.0614628707
GSE19018Up0.1250137273
GSE19899_A1Up0.1699730173
GSE19899_A2Down-0.5292860647
PubMed_21979375_A1Down-0.4939438783
PubMed_21979375_A2Up0.0343286531
GSE35957Down-2.0411422860
GSE36640Down-0.0113010760
GSE54402Down-0.3767443934
GSE9593Down-0.8212558201
GSE43922Up0.0216926083
GSE24585Up0.0322630817
GSE37065Up0.5219415057
GSE28863_A1Up0.7861286745
GSE28863_A2Down-0.1298965694
GSE28863_A3Down-0.0600568708
GSE28863_A4Down-0.3329475024
GSE48662Down-0.1543164150

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018556MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022978MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024567MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026781MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26140238Following sarcoma engraftment, NHS-IL12 therapy was combined with either engineered IL-7 (FcIL-7) or IL-2 (IL-2MAB602) for continuous cytokine bioavailability
26140238NHS-IL12 strongly induced innate and adaptive antitumor immunity when combined with IL-7 or IL-2
24499954DESIGN: IL-7 induced proliferation of, and IL-7 receptor signalling in, total and naive CD4 T cells of HIV patients who had low (<350 cells/mul) or normal (>500 cells/mul) CD4 T-cell counts on ART was examined and related to markers of CD4 T-cell activation and senescence and innate immune activation
24499954Downregulation of CD127 after culture with IL-7 correlated inversely with CD4 T-cell counts and directly with Ki67 expression
24499954CONCLUSION: Defects of IL-7 signalling in HIV patients with persistent CD4 T-cell deficiency receiving ART are associated with CD4 T-cell activation and senescence
22092365METHODS: We investigated parameters of T-cell homeostasis namely the proliferation/apoptotic rate of naive and memory T cells, the T-cell senescence by telomere measurement, the recent thymic T-cell production through quantification of T-cell receptor rearrangement excision circles (TRECs), and the production of interleukin (IL)-7
22092365The TREC content of CD4(+) and CD8(+) cells was lower in patients compared with controls and was correlated with the proportion of CD45RA(+) CD4(+) and CD8(+) cells and with the levels of serum and BM IL-7, which were significantly decreased in the patients
22092365CONCLUSIONS: The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN
20591642Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the periphery
20038483IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis
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