HCSGD entry for IL2RB

1. General information

Official gene symbolIL2RB
Entrez ID3560
Gene full nameinterleukin 2 receptor, beta
Other gene symbolsCD122 IL15RB P70-75
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004911Interleukin-2 receptor activityIDA TASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0009897External side of plasma membraneIEA ISScellular_component
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019976Interleukin-2 bindingIEA ISSmolecular_function
GO:0038110Interleukin-2-mediated signaling pathwayIDA TASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40717044950.51198183960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1514214470
GSE13712_SHEARDown-0.0535201294
GSE13712_STATICDown-0.0883519189
GSE19018Up0.0288682376
GSE19899_A1Up0.1920274269
GSE19899_A2Up0.2917180939
PubMed_21979375_A1Up0.1147510167
PubMed_21979375_A2Up0.0714175073
GSE35957Up0.2685943060
GSE36640Down-0.2507051688
GSE54402Up0.0451292061
GSE9593Down-0.2048109581
GSE43922Up0.2240428236
GSE24585Up0.1722343102
GSE37065Down-0.0144759820
GSE28863_A1Down-0.5143840353
GSE28863_A2Down-0.5944075573
GSE28863_A3Up0.3755273560
GSE28863_A4Up0.0480096867
GSE48662Down-0.0529406544

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Denileukin diftitoxDB00004 BTD00084 | BIOD00084
AldesleukinDB00041 BTD00082 | BIOD00082
BasiliximabDB00074 BTD00073 | BIOD00073
DaclizumabDB00111 BTD00007 | BIOD00007

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18354208They exhibited increased expression of CD122 and CD127, akin to the Ag-independent T cell clonal expansions found in old specific pathogen-free laboratory mice
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