HCSGD entry for IL2RB

1. General information

Official gene symbolIL2RB
Entrez ID3560
Gene full nameinterleukin 2 receptor, beta
Other gene symbolsCD122 IL15RB P70-75
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004911Interleukin-2 receptor activityIDA TASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0009897External side of plasma membraneIEA ISScellular_component
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019976Interleukin-2 bindingIEA ISSmolecular_function
GO:0038110Interleukin-2-mediated signaling pathwayIDA TASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40717044950.51198183960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1514214470
GSE13712_SHEARDown-0.0535201294
GSE13712_STATICDown-0.0883519189
GSE19018Up0.0288682376
GSE19899_A1Up0.1920274269
GSE19899_A2Up0.2917180939
PubMed_21979375_A1Up0.1147510167
PubMed_21979375_A2Up0.0714175073
GSE35957Up0.2685943060
GSE36640Down-0.2507051688
GSE54402Up0.0451292061
GSE9593Down-0.2048109581
GSE43922Up0.2240428236
GSE24585Up0.1722343102
GSE37065Down-0.0144759820
GSE28863_A1Down-0.5143840353
GSE28863_A2Down-0.5944075573
GSE28863_A3Up0.3755273560
GSE28863_A4Up0.0480096867
GSE48662Down-0.0529406544

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Denileukin diftitoxDB00004 BTD00084 | BIOD00084
AldesleukinDB00041 BTD00082 | BIOD00082
BasiliximabDB00074 BTD00073 | BIOD00073
DaclizumabDB00111 BTD00007 | BIOD00007

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18354208They exhibited increased expression of CD122 and CD127, akin to the Ag-independent T cell clonal expansions found in old specific pathogen-free laboratory mice
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