HCSGD entry for RBPJ

1. General information

Official gene symbolRBPJ
Entrez ID3516
Gene full namerecombination signal binding protein for immunoglobulin kappa J region
Other gene symbolsAOS3 CBF1 IGKJRB IGKJRB1 KBF2 RBP-J RBPJK RBPSUH SUH csl
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMP ISSbiological_process
GO:0000150Recombinase activityNASmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001525AngiogenesisIEA ISSbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDAcellular_component
GO:0002437Inflammatory response to antigenic stimulusIEAbiological_process
GO:0003151Outflow tract morphogenesisIEA ISSbiological_process
GO:0003160Endocardium morphogenesisIEA ISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEA ISSbiological_process
GO:0003214Cardiac left ventricle morphogenesisIEA ISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEA ISSbiological_process
GO:0003256Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIEA ISSbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006310DNA recombinationNASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007219Notch signaling pathwayIEA IMP TASbiological_process
GO:0007221Positive regulation of transcription of Notch receptor targetIDAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009912Auditory receptor cell fate commitmentIEAbiological_process
GO:0009957Epidermal cell fate specificationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030279Negative regulation of ossificationIEA ISSbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEA ISSbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035912Dorsal aorta morphogenesisIEA ISSbiological_process
GO:0036302Atrioventricular canal developmentIEA ISSbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048505Regulation of timing of cell differentiationIEAbiological_process
GO:0048733Sebaceous gland developmentIEAbiological_process
GO:0048820Hair follicle maturationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEA ISSbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEA ISSbiological_process
GO:0060844Arterial endothelial cell fate commitmentIEAbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0072554Blood vessel lumenizationIEA ISSbiological_process
GO:0072602Interleukin-4 secretionIEAbiological_process
GO:0097101Blood vessel endothelial cell fate specificationIEA ISSbiological_process
GO:1901186Positive regulation of ERBB signaling pathwayIEA ISSbiological_process
GO:1901189Positive regulation of ephrin receptor signaling pathwayIEA ISSbiological_process
GO:2000138Positive regulation of cell proliferation involved in heart morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20030167170.90254042020.86287538461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0396911511
GSE13712_SHEARDown-0.2441865608
GSE13712_STATICDown-0.0101669246
GSE19018Up0.1044879246
GSE19899_A1Up0.4817402512
GSE19899_A2Up0.4102176710
PubMed_21979375_A1Up0.2236304396
PubMed_21979375_A2Up0.4995580648
GSE35957Up0.1334614089
GSE36640Up0.0781108272
GSE54402Up0.1251831511
GSE9593Up0.0070351597
GSE43922Up0.1330914491
GSE24585Down-0.2141823758
GSE37065Up0.0695034810
GSE28863_A1Up0.1007376844
GSE28863_A2Up0.2505867980
GSE28863_A3Up0.0939946827
GSE28863_A4Down-0.0993154847
GSE48662Down-0.2096410585

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019785MicroarrayFunctional MTI (Weak)20215506
hsa-miR-155-5pMIMAT0000646MIRT020670ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022527Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-18a-5pMIMAT0000072MIRT050652CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052218CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20446924It was previously reported that binding of two transcription factors, C/EBPbeta and RBP-Jkappa, to a regulatory site on the p53 promoter regulates its activity, in vitro, in a cell cycle-dependent manner
20446924RBP-Jkappa participates in the transcriptional regulation of target genes by interacting with the cytoplasmic domain of the Notch receptors
20446924When RBP-Jkappa is released, transcriptional repression of its target genes occurs through the recruitment of co-repressor complexes and prevents transcription from occurring
20446924Our reports, here and previously published, show that repression of p53 by RBP-Jkappa and activation of p53 by C/EBPbeta through differential binding of these two factors indicates a type of co-operative regulation in p53 expression
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