HCSGD entry for RBPJ

1. General information

Official gene symbolRBPJ
Entrez ID3516
Gene full namerecombination signal binding protein for immunoglobulin kappa J region
Other gene symbolsAOS3 CBF1 IGKJRB IGKJRB1 KBF2 RBP-J RBPJK RBPSUH SUH csl
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMP ISSbiological_process
GO:0000150Recombinase activityNASmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001525AngiogenesisIEA ISSbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDAcellular_component
GO:0002437Inflammatory response to antigenic stimulusIEAbiological_process
GO:0003151Outflow tract morphogenesisIEA ISSbiological_process
GO:0003160Endocardium morphogenesisIEA ISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEA ISSbiological_process
GO:0003214Cardiac left ventricle morphogenesisIEA ISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEA ISSbiological_process
GO:0003256Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIEA ISSbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006310DNA recombinationNASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007219Notch signaling pathwayIEA IMP TASbiological_process
GO:0007221Positive regulation of transcription of Notch receptor targetIDAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009912Auditory receptor cell fate commitmentIEAbiological_process
GO:0009957Epidermal cell fate specificationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030279Negative regulation of ossificationIEA ISSbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEA ISSbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035912Dorsal aorta morphogenesisIEA ISSbiological_process
GO:0036302Atrioventricular canal developmentIEA ISSbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048505Regulation of timing of cell differentiationIEAbiological_process
GO:0048733Sebaceous gland developmentIEAbiological_process
GO:0048820Hair follicle maturationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEA ISSbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEA ISSbiological_process
GO:0060844Arterial endothelial cell fate commitmentIEAbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0072554Blood vessel lumenizationIEA ISSbiological_process
GO:0072602Interleukin-4 secretionIEAbiological_process
GO:0097101Blood vessel endothelial cell fate specificationIEA ISSbiological_process
GO:1901186Positive regulation of ERBB signaling pathwayIEA ISSbiological_process
GO:1901189Positive regulation of ephrin receptor signaling pathwayIEA ISSbiological_process
GO:2000138Positive regulation of cell proliferation involved in heart morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20030167170.90254042020.86287538461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0396911511
GSE13712_SHEARDown-0.2441865608
GSE13712_STATICDown-0.0101669246
GSE19018Up0.1044879246
GSE19899_A1Up0.4817402512
GSE19899_A2Up0.4102176710
PubMed_21979375_A1Up0.2236304396
PubMed_21979375_A2Up0.4995580648
GSE35957Up0.1334614089
GSE36640Up0.0781108272
GSE54402Up0.1251831511
GSE9593Up0.0070351597
GSE43922Up0.1330914491
GSE24585Down-0.2141823758
GSE37065Up0.0695034810
GSE28863_A1Up0.1007376844
GSE28863_A2Up0.2505867980
GSE28863_A3Up0.0939946827
GSE28863_A4Down-0.0993154847
GSE48662Down-0.2096410585

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019785MicroarrayFunctional MTI (Weak)20215506
hsa-miR-155-5pMIMAT0000646MIRT020670ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022527Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-18a-5pMIMAT0000072MIRT050652CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052218CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20446924It was previously reported that binding of two transcription factors, C/EBPbeta and RBP-Jkappa, to a regulatory site on the p53 promoter regulates its activity, in vitro, in a cell cycle-dependent manner
20446924RBP-Jkappa participates in the transcriptional regulation of target genes by interacting with the cytoplasmic domain of the Notch receptors
20446924When RBP-Jkappa is released, transcriptional repression of its target genes occurs through the recruitment of co-repressor complexes and prevents transcription from occurring
20446924Our reports, here and previously published, show that repression of p53 by RBP-Jkappa and activation of p53 by C/EBPbeta through differential binding of these two factors indicates a type of co-operative regulation in p53 expression
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