HCSGD entry for APOD

1. General information

Official gene symbolAPOD
Entrez ID347
Gene full nameapolipoprotein D
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000302Response to reactive oxygen speciesIDA IEAbiological_process
GO:0001525AngiogenesisNASbiological_process
GO:0005215Transporter activityIEAmolecular_function
GO:0005319Lipid transporter activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA NAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularIEAcellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0006006Glucose metabolic processIDAbiological_process
GO:0006629Lipid metabolic processIDAbiological_process
GO:0006869Lipid transportNASbiological_process
GO:0007420Brain developmentISSbiological_process
GO:0007568AgingNASbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0014012Peripheral nervous system axon regenerationISSbiological_process
GO:0015485Cholesterol bindingIDAmolecular_function
GO:0022626Cytosolic ribosomeISScellular_component
GO:0030425DendriteISScellular_component
GO:0036094Small molecule bindingIEAmolecular_function
GO:0042246Tissue regenerationISSbiological_process
GO:0042308Negative regulation of protein import into nucleusIDAbiological_process
GO:0042493Response to drugISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0048678Response to axon injuryISSbiological_process
GO:0051895Negative regulation of focal adhesion assemblyIMPbiological_process
GO:0060588Negative regulation of lipoprotein lipid oxidationIDA IEAbiological_process
GO:0071638Negative regulation of monocyte chemotactic protein-1 productionIDAbiological_process
GO:1900016Negative regulation of cytokine production involved in inflammatory responseIDAbiological_process
GO:2000098Negative regulation of smooth muscle cell-matrix adhesionIMPbiological_process
GO:2000405Negative regulation of T cell migrationIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00002500660.99939165690.01490638301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2839240830
GSE13712_SHEARUp0.8896250294
GSE13712_STATICUp0.6572816779
GSE19018Up0.0597453892
GSE19899_A1Up1.2401376337
GSE19899_A2Up1.0216661076
PubMed_21979375_A1Up2.3519424303
PubMed_21979375_A2Up3.2218365278
GSE35957Up0.0401903393
GSE36640Up1.9842194783
GSE54402Up0.3826201660
GSE9593Up2.0417287183
GSE43922Up3.2362435336
GSE24585Up0.6067623719
GSE37065Down-0.1714310315
GSE28863_A1Up0.9803404599
GSE28863_A2Up1.3156970766
GSE28863_A3Up0.7672587004
GSE28863_A4Up0.1775199758
GSE48662Up0.0629075903

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19189975Our results reveal several common signatures of aging, including 56 genes consistently overexpressed with age, the most significant of which was APOD, and 17 genes underexpressed with age
17452772Emerging concepts of apolipoprotein D with possible implications for breast cancer
17452772Apolipoprotein D (ApoD) is a small glycoprotein of 24 kD, and a member of the lipocalin family
17452772ApoD exerts several intracellular mechanistic roles, especially ligand binding
17452772Furthermore, ApoD has features compatible with endosomal trafficking, proteolytic activity and interactions in cellular signal pathways
17452772ApoD inhibits translocation of phosphorylated MAPK into the nucleus
17452772Moreover, ApoD is associated with reduced proliferative activity of cancer cells, and is abundantly raised in senescent cells
17452772In breast cancer, ApoD expression is associated with favourable histology and clinical stage, whereas in adjacent tumour stroma ApoD expression is a marker of adverse prognosis
17452772Oestrogen receptor expression in breast cancer is inversely related to ApoD expression
17452772The triangular relationship between oestrogen receptor, tamoxifen and ApoD should be further explored
Entries Per Page
Displaying Page of