HCSGD entry for APOD
1. General information
Official gene symbol | APOD |
---|---|
Entrez ID | 347 |
Gene full name | apolipoprotein D |
Other gene symbols | |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000302 | Response to reactive oxygen species | IDA IEA | biological_process |
GO:0001525 | Angiogenesis | NAS | biological_process |
GO:0005215 | Transporter activity | IEA | molecular_function |
GO:0005319 | Lipid transporter activity | NAS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005576 | Extracellular region | IEA NAS | cellular_component |
GO:0005615 | Extracellular space | IDA | cellular_component |
GO:0005622 | Intracellular | IEA | cellular_component |
GO:0005783 | Endoplasmic reticulum | ISS | cellular_component |
GO:0006006 | Glucose metabolic process | IDA | biological_process |
GO:0006629 | Lipid metabolic process | IDA | biological_process |
GO:0006869 | Lipid transport | NAS | biological_process |
GO:0007420 | Brain development | ISS | biological_process |
GO:0007568 | Aging | NAS | biological_process |
GO:0008289 | Lipid binding | IEA | molecular_function |
GO:0010642 | Negative regulation of platelet-derived growth factor receptor signaling pathway | IDA | biological_process |
GO:0014012 | Peripheral nervous system axon regeneration | ISS | biological_process |
GO:0015485 | Cholesterol binding | IDA | molecular_function |
GO:0022626 | Cytosolic ribosome | ISS | cellular_component |
GO:0030425 | Dendrite | ISS | cellular_component |
GO:0036094 | Small molecule binding | IEA | molecular_function |
GO:0042246 | Tissue regeneration | ISS | biological_process |
GO:0042308 | Negative regulation of protein import into nucleus | IDA | biological_process |
GO:0042493 | Response to drug | ISS | biological_process |
GO:0043025 | Neuronal cell body | ISS | cellular_component |
GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
GO:0048662 | Negative regulation of smooth muscle cell proliferation | IDA | biological_process |
GO:0048678 | Response to axon injury | ISS | biological_process |
GO:0051895 | Negative regulation of focal adhesion assembly | IMP | biological_process |
GO:0060588 | Negative regulation of lipoprotein lipid oxidation | IDA IEA | biological_process |
GO:0071638 | Negative regulation of monocyte chemotactic protein-1 production | IDA | biological_process |
GO:1900016 | Negative regulation of cytokine production involved in inflammatory response | IDA | biological_process |
GO:2000098 | Negative regulation of smooth muscle cell-matrix adhesion | IMP | biological_process |
GO:2000405 | Negative regulation of T cell migration | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0000250066 | 0.9993916569 | 0.0149063830 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.2839240830 |
GSE13712_SHEAR | Up | 0.8896250294 |
GSE13712_STATIC | Up | 0.6572816779 |
GSE19018 | Up | 0.0597453892 |
GSE19899_A1 | Up | 1.2401376337 |
GSE19899_A2 | Up | 1.0216661076 |
PubMed_21979375_A1 | Up | 2.3519424303 |
PubMed_21979375_A2 | Up | 3.2218365278 |
GSE35957 | Up | 0.0401903393 |
GSE36640 | Up | 1.9842194783 |
GSE54402 | Up | 0.3826201660 |
GSE9593 | Up | 2.0417287183 |
GSE43922 | Up | 3.2362435336 |
GSE24585 | Up | 0.6067623719 |
GSE37065 | Down | -0.1714310315 |
GSE28863_A1 | Up | 0.9803404599 |
GSE28863_A2 | Up | 1.3156970766 |
GSE28863_A3 | Up | 0.7672587004 |
GSE28863_A4 | Up | 0.1775199758 |
GSE48662 | Up | 0.0629075903 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
19189975 | Our results reveal several common signatures of aging, including 56 genes consistently overexpressed with age, the most significant of which was APOD, and 17 genes underexpressed with age |
17452772 | Emerging concepts of apolipoprotein D with possible implications for breast cancer |
17452772 | Apolipoprotein D (ApoD) is a small glycoprotein of 24 kD, and a member of the lipocalin family |
17452772 | ApoD exerts several intracellular mechanistic roles, especially ligand binding |
17452772 | Furthermore, ApoD has features compatible with endosomal trafficking, proteolytic activity and interactions in cellular signal pathways |
17452772 | ApoD inhibits translocation of phosphorylated MAPK into the nucleus |
17452772 | Moreover, ApoD is associated with reduced proliferative activity of cancer cells, and is abundantly raised in senescent cells |
17452772 | In breast cancer, ApoD expression is associated with favourable histology and clinical stage, whereas in adjacent tumour stroma ApoD expression is a marker of adverse prognosis |
17452772 | Oestrogen receptor expression in breast cancer is inversely related to ApoD expression |
17452772 | The triangular relationship between oestrogen receptor, tamoxifen and ApoD should be further explored |
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