HCSGD entry for IDH3A
1. General information
| Official gene symbol | IDH3A |
|---|---|
| Entrez ID | 3419 |
| Gene full name | isocitrate dehydrogenase 3 (NAD+) alpha |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004449 | Isocitrate dehydrogenase (NAD+) activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | NAS | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | TAS | biological_process |
| GO:0016616 | Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0602358611 | 0.5780219900 | 0.5320362752 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3537784986 |
| GSE13712_SHEAR | Up | 0.1541639494 |
| GSE13712_STATIC | Up | 0.0685059506 |
| GSE19018 | Down | -0.5611208431 |
| GSE19899_A1 | Up | 0.3250688148 |
| GSE19899_A2 | Up | 0.3528116804 |
| PubMed_21979375_A1 | Up | 0.3059561570 |
| PubMed_21979375_A2 | Up | 0.4338253186 |
| GSE35957 | Up | 0.2688949488 |
| GSE36640 | Up | 0.4118790794 |
| GSE54402 | Up | 0.3458451769 |
| GSE9593 | Down | -0.3260815843 |
| GSE43922 | Up | 0.2934587066 |
| GSE24585 | Up | 0.0419971674 |
| GSE37065 | Up | 0.0765796706 |
| GSE28863_A1 | Down | -0.4000013868 |
| GSE28863_A2 | Down | -0.0121596529 |
| GSE28863_A3 | Down | -0.4929971098 |
| GSE28863_A4 | Up | 0.4401871795 |
| GSE48662 | Down | -0.4173035846 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031744 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
