HCSGD entry for ACER2

1. General information

Official gene symbolACER2
Entrez ID340485
Gene full namealkaline ceramidase 2
Other gene symbolsALKCDase2 ASAH3L
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001953Negative regulation of cell-matrix adhesionIDAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006672Ceramide metabolic processIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010942Positive regulation of cell deathIMPbiological_process
GO:0017040Ceramidase activityIDAmolecular_function
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0030173Integral component of Golgi membraneIDAcellular_component
GO:0032526Response to retinoic acidIDAbiological_process
GO:0033629Negative regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0035690Cellular response to drugIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046512Sphingosine biosynthetic processIDAbiological_process
GO:0071633Dihydroceramidase activityIDAmolecular_function
GO:0090285Negative regulation of protein glycosylation in GolgiIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18515203450.93570338130.84110919921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.9806899140
GSE24585Up0.7420693036
GSE37065Up0.2789973631
GSE28863_A1Down-0.3247465636
GSE28863_A2Down-0.0174106613
GSE28863_A3Up0.1100413304
GSE28863_A4Up0.1471128987
GSE48662Down-0.0071167866

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.