HCSGD entry for ACER2

1. General information

Official gene symbolACER2
Entrez ID340485
Gene full namealkaline ceramidase 2
Other gene symbolsALKCDase2 ASAH3L
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001953Negative regulation of cell-matrix adhesionIDAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006672Ceramide metabolic processIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010942Positive regulation of cell deathIMPbiological_process
GO:0017040Ceramidase activityIDAmolecular_function
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0030173Integral component of Golgi membraneIDAcellular_component
GO:0032526Response to retinoic acidIDAbiological_process
GO:0033629Negative regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0035690Cellular response to drugIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046512Sphingosine biosynthetic processIDAbiological_process
GO:0071633Dihydroceramidase activityIDAmolecular_function
GO:0090285Negative regulation of protein glycosylation in GolgiIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18515203450.93570338130.84110919921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.9806899140
GSE24585Up0.7420693036
GSE37065Up0.2789973631
GSE28863_A1Down-0.3247465636
GSE28863_A2Down-0.0174106613
GSE28863_A3Up0.1100413304
GSE28863_A4Up0.1471128987
GSE48662Down-0.0071167866

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.