HCSGD entry for APOB

1. General information

Official gene symbolAPOB
Entrez ID338
Gene full nameapolipoprotein B
Other gene symbolsFLDB LDLCQ4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0005319Lipid transporter activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006642Triglyceride mobilizationIEAbiological_process
GO:0006898Receptor-mediated endocytosisTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008203Cholesterol metabolic processIMPbiological_process
GO:0009566FertilizationIEAbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0009743Response to carbohydrateIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0010269Response to selenium ionIEAbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0010884Positive regulation of lipid storageIDAbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0017127Cholesterol transporter activityIMPmolecular_function
GO:0019433Triglyceride catabolic processIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0030301Cholesterol transportIMPbiological_process
GO:0030317Sperm motilityIEAbiological_process
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031904Endosome lumenTAScellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033344Cholesterol effluxIEAbiological_process
GO:0034359Mature chylomicronIDAcellular_component
GO:0034360Chylomicron remnantTAScellular_component
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034362Low-density lipoprotein particleIDAcellular_component
GO:0034363Intermediate-density lipoprotein particleIDAcellular_component
GO:0034374Low-density lipoprotein particle remodelingIMPbiological_process
GO:0034379Very-low-density lipoprotein particle assemblyICbiological_process
GO:0034383Low-density lipoprotein particle clearanceIMPbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042158Lipoprotein biosynthetic processIEAbiological_process
GO:0042159Lipoprotein catabolic processIEAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042953Lipoprotein transportIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045540Regulation of cholesterol biosynthetic processIEAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048844Artery morphogenesisIEAbiological_process
GO:0050750Low-density lipoprotein particle receptor bindingIMPmolecular_function
GO:0050900Leukocyte migrationTASbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071379Cellular response to prostaglandin stimulusIEAbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81270824440.69106897150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0078628288
GSE13712_SHEARUp0.0548614747
GSE13712_STATICUp0.0733594365
GSE19018Up0.0746565442
GSE19899_A1Up0.0329300043
GSE19899_A2Down-0.0729533662
PubMed_21979375_A1Up0.1584080813
PubMed_21979375_A2Down-0.0556531937
GSE35957Up0.0167262168
GSE36640Up0.0197979116
GSE54402Down-0.0068992726
GSE9593Down-0.4916097497
GSE43922Up0.0317115992
GSE24585Down-0.0834046393
GSE37065Down-0.0447403689
GSE28863_A1Down-0.0767547507
GSE28863_A2Up0.0295932140
GSE28863_A3Up0.0635063631
GSE28863_A4Up0.0630044297
GSE48662Up0.0058948217

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.