HCSGD entry for APOB

1. General information

Official gene symbolAPOB
Entrez ID338
Gene full nameapolipoprotein B
Other gene symbolsFLDB LDLCQ4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0005319Lipid transporter activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006642Triglyceride mobilizationIEAbiological_process
GO:0006898Receptor-mediated endocytosisTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008203Cholesterol metabolic processIMPbiological_process
GO:0009566FertilizationIEAbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0009743Response to carbohydrateIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0010269Response to selenium ionIEAbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0010884Positive regulation of lipid storageIDAbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0017127Cholesterol transporter activityIMPmolecular_function
GO:0019433Triglyceride catabolic processIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0030301Cholesterol transportIMPbiological_process
GO:0030317Sperm motilityIEAbiological_process
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031904Endosome lumenTAScellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033344Cholesterol effluxIEAbiological_process
GO:0034359Mature chylomicronIDAcellular_component
GO:0034360Chylomicron remnantTAScellular_component
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034362Low-density lipoprotein particleIDAcellular_component
GO:0034363Intermediate-density lipoprotein particleIDAcellular_component
GO:0034374Low-density lipoprotein particle remodelingIMPbiological_process
GO:0034379Very-low-density lipoprotein particle assemblyICbiological_process
GO:0034383Low-density lipoprotein particle clearanceIMPbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042158Lipoprotein biosynthetic processIEAbiological_process
GO:0042159Lipoprotein catabolic processIEAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042953Lipoprotein transportIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045540Regulation of cholesterol biosynthetic processIEAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048844Artery morphogenesisIEAbiological_process
GO:0050750Low-density lipoprotein particle receptor bindingIMPmolecular_function
GO:0050900Leukocyte migrationTASbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071379Cellular response to prostaglandin stimulusIEAbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81270824440.69106897150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0078628288
GSE13712_SHEARUp0.0548614747
GSE13712_STATICUp0.0733594365
GSE19018Up0.0746565442
GSE19899_A1Up0.0329300043
GSE19899_A2Down-0.0729533662
PubMed_21979375_A1Up0.1584080813
PubMed_21979375_A2Down-0.0556531937
GSE35957Up0.0167262168
GSE36640Up0.0197979116
GSE54402Down-0.0068992726
GSE9593Down-0.4916097497
GSE43922Up0.0317115992
GSE24585Down-0.0834046393
GSE37065Down-0.0447403689
GSE28863_A1Down-0.0767547507
GSE28863_A2Up0.0295932140
GSE28863_A3Up0.0635063631
GSE28863_A4Up0.0630044297
GSE48662Up0.0058948217

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.