HCSGD entry for HTR2C

1. General information

Official gene symbolHTR2C
Entrez ID3358
Gene full name5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Other gene symbols5-HT2C 5-HTR2C HTR1C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001587Gq/11-coupled serotonin receptor activityIDAmolecular_function
GO:0001662Behavioral fear responseISSbiological_process
GO:0004993Serotonin receptor activityIDAmolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIMPcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007208Phospholipase C-activating serotonin receptor signaling pathwayISSbiological_process
GO:0007210Serotonin receptor signaling pathwayIMPbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0007631Feeding behaviorISSbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0010513Positive regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0031644Regulation of neurological system processISSbiological_process
GO:0032098Regulation of appetiteISSbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043397Regulation of corticotropin-releasing hormone secretionISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIMPbiological_process
GO:0051378Serotonin bindingIDAmolecular_function
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66195990270.87243758600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0765937861
GSE13712_SHEARUp0.0338085184
GSE13712_STATICDown-0.0375805124
GSE19018Up0.0224598648
GSE19899_A1Up0.0750170913
GSE19899_A2Up0.0069923504
PubMed_21979375_A1Down-0.0171922810
PubMed_21979375_A2Down-0.0424399577
GSE35957Up0.1797849839
GSE36640Down-0.0971247619
GSE54402Down-0.0114160949
GSE9593Up0.0164022503
GSE43922Up0.0272714077
GSE24585Up0.2649577837
GSE37065Up0.0474489373
GSE28863_A1Down-0.2382519715
GSE28863_A2Down-0.0900462551
GSE28863_A3Up0.3247448115
GSE28863_A4Up0.0539882726
GSE48662Down-0.0015181085

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT005901Luciferase reporter assay//MicroarrayFunctional MTI21168126
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.