HCSGD entry for HTR2C

1. General information

Official gene symbolHTR2C
Entrez ID3358
Gene full name5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Other gene symbols5-HT2C 5-HTR2C HTR1C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001587Gq/11-coupled serotonin receptor activityIDAmolecular_function
GO:0001662Behavioral fear responseISSbiological_process
GO:0004993Serotonin receptor activityIDAmolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIMPcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007208Phospholipase C-activating serotonin receptor signaling pathwayISSbiological_process
GO:0007210Serotonin receptor signaling pathwayIMPbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0007631Feeding behaviorISSbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0010513Positive regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0031644Regulation of neurological system processISSbiological_process
GO:0032098Regulation of appetiteISSbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043397Regulation of corticotropin-releasing hormone secretionISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIMPbiological_process
GO:0051378Serotonin bindingIDAmolecular_function
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66195990270.87243758600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0765937861
GSE13712_SHEARUp0.0338085184
GSE13712_STATICDown-0.0375805124
GSE19018Up0.0224598648
GSE19899_A1Up0.0750170913
GSE19899_A2Up0.0069923504
PubMed_21979375_A1Down-0.0171922810
PubMed_21979375_A2Down-0.0424399577
GSE35957Up0.1797849839
GSE36640Down-0.0971247619
GSE54402Down-0.0114160949
GSE9593Up0.0164022503
GSE43922Up0.0272714077
GSE24585Up0.2649577837
GSE37065Up0.0474489373
GSE28863_A1Down-0.2382519715
GSE28863_A2Down-0.0900462551
GSE28863_A3Up0.3247448115
GSE28863_A4Up0.0539882726
GSE48662Down-0.0015181085

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT005901Luciferase reporter assay//MicroarrayFunctional MTI21168126
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.