HCSGD entry for HTR1A

1. General information

Official gene symbolHTR1A
Entrez ID3350
Gene full name5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Other gene symbols5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001662Behavioral fear responseIEA ISSbiological_process
GO:0004993Serotonin receptor activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDA IEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007198Adenylate cyclase-inhibiting serotonin receptor signaling pathwayIDAbiological_process
GO:0007210Serotonin receptor signaling pathwayISSbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0014062Regulation of serotonin secretionIEA ISSbiological_process
GO:0035640Exploration behaviorIEA ISSbiological_process
GO:0042053Regulation of dopamine metabolic processIEA ISSbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0042428Serotonin metabolic processIEA ISSbiological_process
GO:0046883Regulation of hormone secretionIEAbiological_process
GO:0050795Regulation of behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47488887960.89715847800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0112481170
GSE13712_SHEARDown-0.0763829044
GSE13712_STATICUp0.0035916710
GSE19018Up0.0638591662
GSE19899_A1Up0.0866305601
GSE19899_A2Up0.2820444391
PubMed_21979375_A1Down-0.0675974544
PubMed_21979375_A2Up0.0021365826
GSE35957Down-0.0579754962
GSE36640Down-0.0045309720
GSE54402Up0.0237010781
GSE9593Down-0.0068830476
GSE43922Up0.0622383295
GSE24585Up0.1754029084
GSE37065Down-0.0517626008
GSE28863_A1Down-0.0737856594
GSE28863_A2Up0.1141282050
GSE28863_A3Up0.0189439148
GSE28863_A4Up0.2382813193
GSE48662Up0.1151898017

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018705MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.