HCSGD entry for HTR1A

1. General information

Official gene symbolHTR1A
Entrez ID3350
Gene full name5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Other gene symbols5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001662Behavioral fear responseIEA ISSbiological_process
GO:0004993Serotonin receptor activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDA IEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007198Adenylate cyclase-inhibiting serotonin receptor signaling pathwayIDAbiological_process
GO:0007210Serotonin receptor signaling pathwayISSbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0014062Regulation of serotonin secretionIEA ISSbiological_process
GO:0035640Exploration behaviorIEA ISSbiological_process
GO:0042053Regulation of dopamine metabolic processIEA ISSbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0042428Serotonin metabolic processIEA ISSbiological_process
GO:0046883Regulation of hormone secretionIEAbiological_process
GO:0050795Regulation of behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47488887960.89715847800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0112481170
GSE13712_SHEARDown-0.0763829044
GSE13712_STATICUp0.0035916710
GSE19018Up0.0638591662
GSE19899_A1Up0.0866305601
GSE19899_A2Up0.2820444391
PubMed_21979375_A1Down-0.0675974544
PubMed_21979375_A2Up0.0021365826
GSE35957Down-0.0579754962
GSE36640Down-0.0045309720
GSE54402Up0.0237010781
GSE9593Down-0.0068830476
GSE43922Up0.0622383295
GSE24585Up0.1754029084
GSE37065Down-0.0517626008
GSE28863_A1Down-0.0737856594
GSE28863_A2Up0.1141282050
GSE28863_A3Up0.0189439148
GSE28863_A4Up0.2382813193
GSE48662Up0.1151898017

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018705MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.