HCSGD entry for HSPB1

1. General information

Official gene symbolHSPB1
Entrez ID3315
Gene full nameheat shock 27kDa protein 1
Other gene symbolsCMT2F HMN2B HS.76067 HSP27 HSP28 Hsp25 SRP27
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000502Proteasome complexISScellular_component
GO:0005080Protein kinase C bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006446Regulation of translational initiationTASbiological_process
GO:0006469Negative regulation of protein kinase activityISSbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0006986Response to unfolded proteinNASbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008426Protein kinase C inhibitor activityIEA ISSmolecular_function
GO:0009615Response to virusIEPbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030018Z discIEAcellular_component
GO:0032731Positive regulation of interleukin-1 beta productionIEA ISSbiological_process
GO:0035556Intracellular signal transductionIMPbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIMPbiological_process
GO:0038033Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayIMPbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIEA ISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIEA ISSbiological_process
GO:0043130Ubiquitin bindingISSmolecular_function
GO:0043536Positive regulation of blood vessel endothelial cell migrationIMPbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0071901Negative regulation of protein serine/threonine kinase activityISSbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIEA ISSbiological_process
GO:2001028Positive regulation of endothelial cell chemotaxisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82594999430.01452539040.99999024730.2368790582

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3381801943
GSE13712_SHEARUp0.0691780237
GSE13712_STATICDown-0.2357412169
GSE19018Down-0.5306455932
GSE19899_A1Down-1.4157235552
GSE19899_A2Down-0.5096516183
PubMed_21979375_A1Up0.0764609712
PubMed_21979375_A2Down-0.9357497611
GSE35957Up0.1416225348
GSE36640Up0.3148759081
GSE54402Down-0.5905085641
GSE9593Up0.0168924869
GSE43922Down-0.4445673606
GSE24585Up0.1634489415
GSE37065Down-0.2279520492
GSE28863_A1Down-0.0202109218
GSE28863_A2Down-0.1056375968
GSE28863_A3Up0.4926003770
GSE28863_A4Down-0.2273148810
GSE48662Up0.2714082314

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OGX-427DB06094 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.