HCSGD entry for HSPB1

1. General information

Official gene symbolHSPB1
Entrez ID3315
Gene full nameheat shock 27kDa protein 1
Other gene symbolsCMT2F HMN2B HS.76067 HSP27 HSP28 Hsp25 SRP27
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000502Proteasome complexISScellular_component
GO:0005080Protein kinase C bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006446Regulation of translational initiationTASbiological_process
GO:0006469Negative regulation of protein kinase activityISSbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0006986Response to unfolded proteinNASbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008426Protein kinase C inhibitor activityIEA ISSmolecular_function
GO:0009615Response to virusIEPbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030018Z discIEAcellular_component
GO:0032731Positive regulation of interleukin-1 beta productionIEA ISSbiological_process
GO:0035556Intracellular signal transductionIMPbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIMPbiological_process
GO:0038033Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayIMPbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIEA ISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIEA ISSbiological_process
GO:0043130Ubiquitin bindingISSmolecular_function
GO:0043536Positive regulation of blood vessel endothelial cell migrationIMPbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0071901Negative regulation of protein serine/threonine kinase activityISSbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIEA ISSbiological_process
GO:2001028Positive regulation of endothelial cell chemotaxisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82594999430.01452539040.99999024730.2368790582

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3381801943
GSE13712_SHEARUp0.0691780237
GSE13712_STATICDown-0.2357412169
GSE19018Down-0.5306455932
GSE19899_A1Down-1.4157235552
GSE19899_A2Down-0.5096516183
PubMed_21979375_A1Up0.0764609712
PubMed_21979375_A2Down-0.9357497611
GSE35957Up0.1416225348
GSE36640Up0.3148759081
GSE54402Down-0.5905085641
GSE9593Up0.0168924869
GSE43922Down-0.4445673606
GSE24585Up0.1634489415
GSE37065Down-0.2279520492
GSE28863_A1Down-0.0202109218
GSE28863_A2Down-0.1056375968
GSE28863_A3Up0.4926003770
GSE28863_A4Down-0.2273148810
GSE48662Up0.2714082314

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OGX-427DB06094 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.