HCSGD entry for HSD17B1

1. General information

Official gene symbolHSD17B1
Entrez ID3292
Gene full namehydroxysteroid (17-beta) dehydrogenase 1
Other gene symbolsEDH17B2 EDHB17 HSD17 SDR28C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003824Catalytic activityTASmolecular_function
GO:0004303Estradiol 17-beta-dehydrogenase activityTASmolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006694Steroid biosynthetic processTASbiological_process
GO:0006703Estrogen biosynthetic processIEA TASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008210Estrogen metabolic processTASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0061370Testosterone biosynthetic processIEAbiological_process
GO:0071248Cellular response to metal ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46087952590.64036829530.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2098826117
GSE13712_SHEARDown-0.1159109117
GSE13712_STATICUp0.0024081387
GSE19018Up0.0477842156
GSE19899_A1Down-0.0640294617
GSE19899_A2Up0.7563844342
PubMed_21979375_A1Down-0.2312787660
PubMed_21979375_A2Up0.2592026187
GSE35957Up0.0032874003
GSE36640Up0.0687885193
GSE54402Up0.1931516824
GSE9593Down-0.2013920201
GSE43922Up0.0455206943
GSE24585Up0.0083506200
GSE37065Down-0.0968718826
GSE28863_A1Down-0.0066929568
GSE28863_A2Down-0.0438806116
GSE28863_A3Up0.1776753611
GSE28863_A4Down-0.0348682477
GSE48662Up0.2078131016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
4-AndrostenedioneDB01536 EXPT00569 | DB07386
AndrostanedioneDB01561 DB03620
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
EquilinDB02187 EXPT01355
EM-1745DB02323 EXPT01802
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.