HCSGD entry for HSD3B1

1. General information

Official gene symbolHSD3B1
Entrez ID3283
Gene full namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Other gene symbols3BETAHSD HSD3B HSDB3 HSDB3A I SDR11E1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIEA ISSmolecular_function
GO:0004769Steroid delta-isomerase activityISSmolecular_function
GO:0005743Mitochondrial inner membraneIDAcellular_component
GO:0005758Mitochondrial intermembrane spaceIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006694Steroid biosynthetic processIEA ISSbiological_process
GO:0006702Androgen biosynthetic processTASbiological_process
GO:0006703Estrogen biosynthetic processTASbiological_process
GO:0006704Glucocorticoid biosynthetic processTASbiological_process
GO:0006705Mineralocorticoid biosynthetic processTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030868Smooth endoplasmic reticulum membraneISScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38915140380.94638077200.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0686801849
GSE13712_SHEARUp0.0537090259
GSE13712_STATICUp0.0504101272
GSE19018Up0.3383900129
GSE19899_A1Down-0.0065197119
GSE19899_A2Down-0.0728254695
PubMed_21979375_A1Up0.4161176385
PubMed_21979375_A2Down-0.0622850054
GSE35957Up0.1272909094
GSE36640Up0.0520057991
GSE54402Up0.2284937802
GSE9593Down-0.0110095144
GSE43922Up0.0252775927
GSE24585Up0.0655070698
GSE37065Down-0.0408877476
GSE28863_A1Up0.1401812123
GSE28863_A2Up0.1628167200
GSE28863_A3Up0.0662167554
GSE28863_A4Up0.0026862043
GSE48662Down-0.0034026198

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
TrilostaneDB01108 APRD01276
4-AndrostenedioneDB01536 EXPT00569 | DB07386

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029754MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.