HCSGD entry for HSD3B1
1. General information
| Official gene symbol | HSD3B1 |
|---|---|
| Entrez ID | 3283 |
| Gene full name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
| Other gene symbols | 3BETAHSD HSD3B HSDB3 HSDB3A I SDR11E1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | IEA ISS | molecular_function |
| GO:0004769 | Steroid delta-isomerase activity | ISS | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | IDA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006694 | Steroid biosynthetic process | IEA ISS | biological_process |
| GO:0006702 | Androgen biosynthetic process | TAS | biological_process |
| GO:0006703 | Estrogen biosynthetic process | TAS | biological_process |
| GO:0006704 | Glucocorticoid biosynthetic process | TAS | biological_process |
| GO:0006705 | Mineralocorticoid biosynthetic process | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030868 | Smooth endoplasmic reticulum membrane | ISS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3891514038 | 0.9463807720 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0686801849 |
| GSE13712_SHEAR | Up | 0.0537090259 |
| GSE13712_STATIC | Up | 0.0504101272 |
| GSE19018 | Up | 0.3383900129 |
| GSE19899_A1 | Down | -0.0065197119 |
| GSE19899_A2 | Down | -0.0728254695 |
| PubMed_21979375_A1 | Up | 0.4161176385 |
| PubMed_21979375_A2 | Down | -0.0622850054 |
| GSE35957 | Up | 0.1272909094 |
| GSE36640 | Up | 0.0520057991 |
| GSE54402 | Up | 0.2284937802 |
| GSE9593 | Down | -0.0110095144 |
| GSE43922 | Up | 0.0252775927 |
| GSE24585 | Up | 0.0655070698 |
| GSE37065 | Down | -0.0408877476 |
| GSE28863_A1 | Up | 0.1401812123 |
| GSE28863_A2 | Up | 0.1628167200 |
| GSE28863_A3 | Up | 0.0662167554 |
| GSE28863_A4 | Up | 0.0026862043 |
| GSE48662 | Down | -0.0034026198 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Trilostane | DB01108 | APRD01276 |
| 4-Androstenedione | DB01536 | EXPT00569 | DB07386 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029754 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
