HCSGD entry for HRH2
1. General information
| Official gene symbol | HRH2 |
|---|---|
| Entrez ID | 3274 |
| Gene full name | histamine receptor H2 |
| Other gene symbols | H2R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001697 | Histamine-induced gastric acid secretion | IEA | biological_process |
| GO:0001698 | Gastrin-induced gastric acid secretion | IEA | biological_process |
| GO:0003382 | Epithelial cell morphogenesis | IEA | biological_process |
| GO:0004969 | Histamine receptor activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | biological_process |
| GO:0007613 | Memory | IEA | biological_process |
| GO:0008542 | Visual learning | IEA | biological_process |
| GO:0045907 | Positive regulation of vasoconstriction | IEA | biological_process |
| GO:0048167 | Regulation of synaptic plasticity | IEA | biological_process |
| GO:0048565 | Digestive tract development | IEA | biological_process |
| GO:0048732 | Gland development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5706340071 | 0.6677178299 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1558873283 |
| GSE13712_SHEAR | Down | -0.3115426532 |
| GSE13712_STATIC | Up | 0.0111492302 |
| GSE19018 | Up | 0.0258460826 |
| GSE19899_A1 | Up | 0.0544060921 |
| GSE19899_A2 | Up | 0.0985046786 |
| PubMed_21979375_A1 | Up | 0.1005825266 |
| PubMed_21979375_A2 | Down | -0.0471088909 |
| GSE35957 | Up | 0.3295537140 |
| GSE36640 | Up | 0.0559917431 |
| GSE54402 | Down | -0.0877782712 |
| GSE9593 | Up | 0.0694295767 |
| GSE43922 | Up | 0.1014453959 |
| GSE24585 | Down | -0.0551808984 |
| GSE37065 | Down | -0.0956564341 |
| GSE28863_A1 | Down | -0.2720833165 |
| GSE28863_A2 | Down | -0.0214972675 |
| GSE28863_A3 | Up | 0.3446582899 |
| GSE28863_A4 | Up | 0.2683491018 |
| GSE48662 | Down | -0.0360210537 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Betazole | DB00272 | APRD00714 |
| Olanzapine | DB00334 | APRD00138 |
| Loxapine | DB00408 | APRD00574 |
| Nizatidine | DB00585 | APRD00706 |
| Histamine Phosphate | DB00667 | APRD01015 |
| Epinastine | DB00751 | APRD00043 |
| Tolazoline | DB00797 | APRD00170 |
| Ranitidine | DB00863 | APRD00254 |
| Methantheline | DB00940 | APRD00751 |
| Doxepin | DB01142 | APRD00398 |
| HZT-501 | DB05369 | - |
| histamine dihydrochloride | DB05381 | - |
| Asenapine | DB06216 | - |
| Metiamide | DB08805 | - |
| Roxatidine acetate | DB08806 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016874 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
