HCSGD entry for HRH2

1. General information

Official gene symbolHRH2
Entrez ID3274
Gene full namehistamine receptor H2
Other gene symbolsH2R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001697Histamine-induced gastric acid secretionIEAbiological_process
GO:0001698Gastrin-induced gastric acid secretionIEAbiological_process
GO:0003382Epithelial cell morphogenesisIEAbiological_process
GO:0004969Histamine receptor activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006955Immune responseTASbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0045907Positive regulation of vasoconstrictionIEAbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048732Gland developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57063400710.66771782990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1558873283
GSE13712_SHEARDown-0.3115426532
GSE13712_STATICUp0.0111492302
GSE19018Up0.0258460826
GSE19899_A1Up0.0544060921
GSE19899_A2Up0.0985046786
PubMed_21979375_A1Up0.1005825266
PubMed_21979375_A2Down-0.0471088909
GSE35957Up0.3295537140
GSE36640Up0.0559917431
GSE54402Down-0.0877782712
GSE9593Up0.0694295767
GSE43922Up0.1014453959
GSE24585Down-0.0551808984
GSE37065Down-0.0956564341
GSE28863_A1Down-0.2720833165
GSE28863_A2Down-0.0214972675
GSE28863_A3Up0.3446582899
GSE28863_A4Up0.2683491018
GSE48662Down-0.0360210537

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BetazoleDB00272 APRD00714
OlanzapineDB00334 APRD00138
LoxapineDB00408 APRD00574
NizatidineDB00585 APRD00706
Histamine PhosphateDB00667 APRD01015
EpinastineDB00751 APRD00043
TolazolineDB00797 APRD00170
RanitidineDB00863 APRD00254
MethanthelineDB00940 APRD00751
DoxepinDB01142 APRD00398
HZT-501DB05369 -
histamine dihydrochlorideDB05381 -
AsenapineDB06216 -
MetiamideDB08805 -
Roxatidine acetateDB08806 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016874MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.