HCSGD entry for HPGD
1. General information
| Official gene symbol | HPGD |
|---|---|
| Entrez ID | 3248 |
| Gene full name | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| Other gene symbols | 15-PGDH PGDH PGDH1 PHOAR1 SDR36C1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IDA | molecular_function |
| GO:0004957 | Prostaglandin E receptor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0006693 | Prostaglandin metabolic process | IDA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0007565 | Female pregnancy | IDA | biological_process |
| GO:0007567 | Parturition | IDA | biological_process |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | IDA NAS TAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019371 | Cyclooxygenase pathway | TAS | biological_process |
| GO:0019372 | Lipoxygenase pathway | TAS | biological_process |
| GO:0030728 | Ovulation | ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | TAS | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045786 | Negative regulation of cell cycle | IDA | biological_process |
| GO:0051287 | NAD binding | IDA | molecular_function |
| GO:0070403 | NAD+ binding | IDA | molecular_function |
| GO:0070493 | Thrombin receptor signaling pathway | IEA ISS | biological_process |
| GO:0097070 | Ductus arteriosus closure | IEA ISS | biological_process |
| GO:2001300 | Lipoxin metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8203995365 | 0.7920178679 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0523936211 |
| GSE13712_SHEAR | Down | -0.0447187936 |
| GSE13712_STATIC | Up | 0.0448119975 |
| GSE19018 | Up | 0.1452801261 |
| GSE19899_A1 | Up | 0.1092766041 |
| GSE19899_A2 | Down | -0.0146502428 |
| PubMed_21979375_A1 | Down | -0.1322001649 |
| PubMed_21979375_A2 | Up | 0.0491842751 |
| GSE35957 | Down | -0.0093451803 |
| GSE36640 | Up | 0.0461234362 |
| GSE54402 | Up | 0.0816446524 |
| GSE9593 | Up | 0.0353260298 |
| GSE43922 | Up | 0.0167074975 |
| GSE24585 | Down | -0.4668735270 |
| GSE37065 | Up | 0.0613474773 |
| GSE28863_A1 | Down | -0.0215303995 |
| GSE28863_A2 | Up | 0.0184340505 |
| GSE28863_A3 | Up | 0.1393305072 |
| GSE28863_A4 | Up | 0.0399168393 |
| GSE48662 | Up | 0.0527338188 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
