HCSGD entry for HPGD

1. General information

Official gene symbolHPGD
Entrez ID3248
Gene full namehydroxyprostaglandin dehydrogenase 15-(NAD)
Other gene symbols15-PGDH PGDH PGDH1 PHOAR1 SDR36C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003824Catalytic activityIDAmolecular_function
GO:0004957Prostaglandin E receptor activityIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolNAS TAScellular_component
GO:0006693Prostaglandin metabolic processIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007565Female pregnancyIDAbiological_process
GO:0007567ParturitionIDAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activityIDA NAS TASmolecular_function
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019371Cyclooxygenase pathwayTASbiological_process
GO:0019372Lipoxygenase pathwayTASbiological_process
GO:0030728OvulationISSbiological_process
GO:0042803Protein homodimerization activityTASmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0051287NAD bindingIDAmolecular_function
GO:0070403NAD+ bindingIDAmolecular_function
GO:0070493Thrombin receptor signaling pathwayIEA ISSbiological_process
GO:0097070Ductus arteriosus closureIEA ISSbiological_process
GO:2001300Lipoxin metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82039953650.79201786790.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0523936211
GSE13712_SHEARDown-0.0447187936
GSE13712_STATICUp0.0448119975
GSE19018Up0.1452801261
GSE19899_A1Up0.1092766041
GSE19899_A2Down-0.0146502428
PubMed_21979375_A1Down-0.1322001649
PubMed_21979375_A2Up0.0491842751
GSE35957Down-0.0093451803
GSE36640Up0.0461234362
GSE54402Up0.0816446524
GSE9593Up0.0353260298
GSE43922Up0.0167074975
GSE24585Down-0.4668735270
GSE37065Up0.0613474773
GSE28863_A1Down-0.0215303995
GSE28863_A2Up0.0184340505
GSE28863_A3Up0.1393305072
GSE28863_A4Up0.0399168393
GSE48662Up0.0527338188

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.