HCSGD entry for APAF1

1. General information

Official gene symbolAPAF1
Entrez ID317
Gene full nameapoptotic peptidase activating factor 1
Other gene symbolsAPAF-1 CED4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingTASmolecular_function
GO:0001843Neural tube closureIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006309Apoptotic DNA fragmentationIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008635Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cIDA TASbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processNASmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0042981Regulation of apoptotic processIEA TASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043293ApoptosomeIDA TAScellular_component
GO:0043531ADP bindingIEAmolecular_function
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0072432Response to G1 DNA damage checkpoint signalingTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37750814180.40756928310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1468673099
GSE13712_SHEARUp0.4435956506
GSE13712_STATICUp0.2649844770
GSE19018Up0.1892652881
GSE19899_A1Up0.1105654302
GSE19899_A2Down-0.4958292738
PubMed_21979375_A1Up0.1086013063
PubMed_21979375_A2Down-0.1395784507
GSE35957Down-0.4635370195
GSE36640Down-0.4907508543
GSE54402Up0.1366505778
GSE9593Down-0.2939120601
GSE43922Up0.0635635586
GSE24585Up0.4101106059
GSE37065Up0.0296326220
GSE28863_A1Up0.2116148034
GSE28863_A2Up0.3807678936
GSE28863_A3Down-0.5627745999
GSE28863_A4Up0.1023914606
GSE48662Down-0.0960932657

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT002410Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT002410MicroarrayFunctional MTI (Weak)18591254
hsa-miR-335-5pMIMAT0000765MIRT018166MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020853Reporter assay;OtherFunctional MTI20584899
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2117991735
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27208501At the same time, TIS21 increased APAF-1 and p53AIP1 expressions, but inhibited the interaction of p53 with iASPP
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