HCSGD entry for APAF1

1. General information

Official gene symbolAPAF1
Entrez ID317
Gene full nameapoptotic peptidase activating factor 1
Other gene symbolsAPAF-1 CED4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingTASmolecular_function
GO:0001843Neural tube closureIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006309Apoptotic DNA fragmentationIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008635Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cIDA TASbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processNASmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0042981Regulation of apoptotic processIEA TASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043293ApoptosomeIDA TAScellular_component
GO:0043531ADP bindingIEAmolecular_function
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0072432Response to G1 DNA damage checkpoint signalingTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37750814180.40756928310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1468673099
GSE13712_SHEARUp0.4435956506
GSE13712_STATICUp0.2649844770
GSE19018Up0.1892652881
GSE19899_A1Up0.1105654302
GSE19899_A2Down-0.4958292738
PubMed_21979375_A1Up0.1086013063
PubMed_21979375_A2Down-0.1395784507
GSE35957Down-0.4635370195
GSE36640Down-0.4907508543
GSE54402Up0.1366505778
GSE9593Down-0.2939120601
GSE43922Up0.0635635586
GSE24585Up0.4101106059
GSE37065Up0.0296326220
GSE28863_A1Up0.2116148034
GSE28863_A2Up0.3807678936
GSE28863_A3Down-0.5627745999
GSE28863_A4Up0.1023914606
GSE48662Down-0.0960932657

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT002410Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT002410MicroarrayFunctional MTI (Weak)18591254
hsa-miR-335-5pMIMAT0000765MIRT018166MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020853Reporter assay;OtherFunctional MTI20584899
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2117991735
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27208501At the same time, TIS21 increased APAF-1 and p53AIP1 expressions, but inhibited the interaction of p53 with iASPP
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