HCSGD entry for NR4A1

1. General information

Official gene symbolNR4A1
Entrez ID3164
Gene full namenuclear receptor subfamily 4, group A, member 1
Other gene symbolsGFRP1 HMR N10 NAK-1 NGFIB NP10 NUR77 TR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0003677DNA bindingIEA ISSmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0035767Endothelial cell chemotaxisIMPbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044344Cellular response to fibroblast growth factor stimulusIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0071310Cellular response to organic substanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66512080090.14009453670.99999024730.7204447502

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2008766475
GSE13712_SHEARDown-0.0357851383
GSE13712_STATICDown-0.0598808980
GSE19018Up0.0379288458
GSE19899_A1Down-0.3146386538
GSE19899_A2Up0.0663498853
PubMed_21979375_A1Up0.0803168193
PubMed_21979375_A2Down-0.0856268701
GSE35957Down-0.0833754862
GSE36640Down-0.1311152892
GSE54402Down-0.2316314412
GSE9593Down-0.1738850724
GSE43922Up0.0520178122
GSE24585Up0.1488239801
GSE37065Up0.8358440906
GSE28863_A1Up0.0108719488
GSE28863_A2Down-0.2108195534
GSE28863_A3Up0.1138792479
GSE28863_A4Down-0.0115168535
GSE48662Up0.1020182562

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018925MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT023110MicroarrayFunctional MTI (Weak)18668037
hsa-miR-196a-5pMIMAT0000226MIRT026031SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032110SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT048853CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9636656The clone, tentatively named N-10, was 1272 bp in length coding for 232 amino acids
9636656Enforced expression of N-10 resulted in premature senescence in young fibroblasts
9636656The deduced amino acid sequence of N-10 was identical to the recently reported hVti1 gene except in one amino acid: Asp24(GAC) was ours and Asn24 (AAC) was reported
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