HCSGD entry for NR4A1

1. General information

Official gene symbolNR4A1
Entrez ID3164
Gene full namenuclear receptor subfamily 4, group A, member 1
Other gene symbolsGFRP1 HMR N10 NAK-1 NGFIB NP10 NUR77 TR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0003677DNA bindingIEA ISSmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0035767Endothelial cell chemotaxisIMPbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044344Cellular response to fibroblast growth factor stimulusIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0071310Cellular response to organic substanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66512080090.14009453670.99999024730.7204447502

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2008766475
GSE13712_SHEARDown-0.0357851383
GSE13712_STATICDown-0.0598808980
GSE19018Up0.0379288458
GSE19899_A1Down-0.3146386538
GSE19899_A2Up0.0663498853
PubMed_21979375_A1Up0.0803168193
PubMed_21979375_A2Down-0.0856268701
GSE35957Down-0.0833754862
GSE36640Down-0.1311152892
GSE54402Down-0.2316314412
GSE9593Down-0.1738850724
GSE43922Up0.0520178122
GSE24585Up0.1488239801
GSE37065Up0.8358440906
GSE28863_A1Up0.0108719488
GSE28863_A2Down-0.2108195534
GSE28863_A3Up0.1138792479
GSE28863_A4Down-0.0115168535
GSE48662Up0.1020182562

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018925MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT023110MicroarrayFunctional MTI (Weak)18668037
hsa-miR-196a-5pMIMAT0000226MIRT026031SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032110SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT048853CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9636656The clone, tentatively named N-10, was 1272 bp in length coding for 232 amino acids
9636656Enforced expression of N-10 resulted in premature senescence in young fibroblasts
9636656The deduced amino acid sequence of N-10 was identical to the recently reported hVti1 gene except in one amino acid: Asp24(GAC) was ours and Asn24 (AAC) was reported
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