HCSGD entry for HMGB2

1. General information

Official gene symbolHMGB2
Entrez ID3148
Gene full namehigh mobility group box 2
Other gene symbolsHMG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000793Condensed chromosomeIDAcellular_component
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0003677DNA bindingIEA IMPmolecular_function
GO:0003684Damaged DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingISSmolecular_function
GO:0003697Single-stranded DNA bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006265DNA topological changeISSbiological_process
GO:0006288Base-excision repair, DNA ligationIDAbiological_process
GO:0006309Apoptotic DNA fragmentationTASbiological_process
GO:0006325Chromatin organizationNASbiological_process
GO:0006334Nucleosome assemblyNASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007289Spermatid nucleus differentiationIEAbiological_process
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0008584Male gonad developmentIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0032075Positive regulation of nuclease activityIDAbiological_process
GO:0033151V(D)J recombinationISSbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043388Positive regulation of DNA bindingIDA IEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045648Positive regulation of erythrocyte differentiationIMPbiological_process
GO:0045654Positive regulation of megakaryocyte differentiationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0050786RAGE receptor bindingIGImolecular_function
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051103DNA ligation involved in DNA repairISSbiological_process
GO:0060326Cell chemotaxisIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEPbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99724268450.00016002430.99999024730.0228913043

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8450253210
GSE13712_SHEARDown-0.2261356338
GSE13712_STATICDown-0.2884929209
GSE19018Up0.3227258800
GSE19899_A1Down-2.1634476015
GSE19899_A2Down-1.6246674162
PubMed_21979375_A1Down-1.5933278481
PubMed_21979375_A2Down-2.4173590054
GSE35957Down-0.8939532600
GSE36640Down-1.6199061012
GSE54402Down-0.4059312140
GSE9593Down-0.8081201912
GSE43922Down-2.1628527480
GSE24585Up0.0831965593
GSE37065Down-0.5588036475
GSE28863_A1Down-0.4068428916
GSE28863_A2Down-0.2015424561
GSE28863_A3Down-0.2809115344
GSE28863_A4Up0.0642922468
GSE48662Down-1.3251924115

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025152MicroarrayFunctional MTI (Weak)17612493
hsa-miR-33a-5pMIMAT0000091MIRT028203SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030580MicroarrayFunctional MTI (Weak)19748357
hsa-miR-374a-5pMIMAT0000727MIRT044016CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23969227A loss of the chromatin protein HMGB2 was demonstrated not only in various telomerase-inhibited clones of different tumor cell lines, but also in normal human fibroblasts undergoing replicative senescence and in aging telomerase knockout mice
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