HCSGD entry for HMGB2

1. General information

Official gene symbolHMGB2
Entrez ID3148
Gene full namehigh mobility group box 2
Other gene symbolsHMG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000793Condensed chromosomeIDAcellular_component
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0003677DNA bindingIEA IMPmolecular_function
GO:0003684Damaged DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingISSmolecular_function
GO:0003697Single-stranded DNA bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006265DNA topological changeISSbiological_process
GO:0006288Base-excision repair, DNA ligationIDAbiological_process
GO:0006309Apoptotic DNA fragmentationTASbiological_process
GO:0006325Chromatin organizationNASbiological_process
GO:0006334Nucleosome assemblyNASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007289Spermatid nucleus differentiationIEAbiological_process
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0008584Male gonad developmentIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0032075Positive regulation of nuclease activityIDAbiological_process
GO:0033151V(D)J recombinationISSbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043388Positive regulation of DNA bindingIDA IEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045648Positive regulation of erythrocyte differentiationIMPbiological_process
GO:0045654Positive regulation of megakaryocyte differentiationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0050786RAGE receptor bindingIGImolecular_function
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051103DNA ligation involved in DNA repairISSbiological_process
GO:0060326Cell chemotaxisIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEPbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99724268450.00016002430.99999024730.0228913043

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8450253210
GSE13712_SHEARDown-0.2261356338
GSE13712_STATICDown-0.2884929209
GSE19018Up0.3227258800
GSE19899_A1Down-2.1634476015
GSE19899_A2Down-1.6246674162
PubMed_21979375_A1Down-1.5933278481
PubMed_21979375_A2Down-2.4173590054
GSE35957Down-0.8939532600
GSE36640Down-1.6199061012
GSE54402Down-0.4059312140
GSE9593Down-0.8081201912
GSE43922Down-2.1628527480
GSE24585Up0.0831965593
GSE37065Down-0.5588036475
GSE28863_A1Down-0.4068428916
GSE28863_A2Down-0.2015424561
GSE28863_A3Down-0.2809115344
GSE28863_A4Up0.0642922468
GSE48662Down-1.3251924115

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025152MicroarrayFunctional MTI (Weak)17612493
hsa-miR-33a-5pMIMAT0000091MIRT028203SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030580MicroarrayFunctional MTI (Weak)19748357
hsa-miR-374a-5pMIMAT0000727MIRT044016CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23969227A loss of the chromatin protein HMGB2 was demonstrated not only in various telomerase-inhibited clones of different tumor cell lines, but also in normal human fibroblasts undergoing replicative senescence and in aging telomerase knockout mice
Entries Per Page
Displaying Page of