HCSGD entry for HLA-DRB1

1. General information

Official gene symbolHLA-DRB1
Entrez ID3123
Gene full namemajor histocompatibility complex, class II, DR beta 1
Other gene symbolsDRB1 DRw10 HLA-DR1B HLA-DRB SS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002381Immunoglobulin production involved in immunoglobulin mediated immune responseIDA ISSbiological_process
GO:0002437Inflammatory response to antigenic stimulusIDA ISSbiological_process
GO:0002455Humoral immune response mediated by circulating immunoglobulinIDA ISSbiological_process
GO:0002862Negative regulation of inflammatory response to antigenic stimulusIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005765Lysosomal membraneIDA TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006955Immune responseIDA IMP ISS NAS TASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0009897External side of plasma membraneIDA ISScellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016020MembraneNAS TAScellular_component
GO:0016045Detection of bacteriumIMP ISSbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0031902Late endosome membraneIDAcellular_component
GO:0032395MHC class II receptor activityNAS TASmolecular_function
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0032673Regulation of interleukin-4 productionIDA ISSbiological_process
GO:0032689Negative regulation of interferon-gamma productionIMP ISSbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIMP ISSbiological_process
GO:0042088T-helper 1 type immune responseIMP ISSbiological_process
GO:0042130Negative regulation of T cell proliferationIMP ISSbiological_process
GO:0042605Peptide antigen bindingIDA ISSmolecular_function
GO:0042613MHC class II protein complexIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051262Protein tetramerizationIDA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:2001179Regulation of interleukin-10 secretionIDA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95147750090.58059996580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.3213560773
GSE28863_A2Down-0.0265212643
GSE28863_A3Up0.1185983659
GSE28863_A4Up0.0543427593
GSE48662Down-0.0777999067

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.