HCSGD entry for HLA-DRB1

1. General information

Official gene symbolHLA-DRB1
Entrez ID3123
Gene full namemajor histocompatibility complex, class II, DR beta 1
Other gene symbolsDRB1 DRw10 HLA-DR1B HLA-DRB SS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002381Immunoglobulin production involved in immunoglobulin mediated immune responseIDA ISSbiological_process
GO:0002437Inflammatory response to antigenic stimulusIDA ISSbiological_process
GO:0002455Humoral immune response mediated by circulating immunoglobulinIDA ISSbiological_process
GO:0002862Negative regulation of inflammatory response to antigenic stimulusIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005765Lysosomal membraneIDA TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006955Immune responseIDA IMP ISS NAS TASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0009897External side of plasma membraneIDA ISScellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016020MembraneNAS TAScellular_component
GO:0016045Detection of bacteriumIMP ISSbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0031902Late endosome membraneIDAcellular_component
GO:0032395MHC class II receptor activityNAS TASmolecular_function
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0032673Regulation of interleukin-4 productionIDA ISSbiological_process
GO:0032689Negative regulation of interferon-gamma productionIMP ISSbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIMP ISSbiological_process
GO:0042088T-helper 1 type immune responseIMP ISSbiological_process
GO:0042130Negative regulation of T cell proliferationIMP ISSbiological_process
GO:0042605Peptide antigen bindingIDA ISSmolecular_function
GO:0042613MHC class II protein complexIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051262Protein tetramerizationIDA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:2001179Regulation of interleukin-10 secretionIDA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95147750090.58059996580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.3213560773
GSE28863_A2Down-0.0265212643
GSE28863_A3Up0.1185983659
GSE28863_A4Up0.0543427593
GSE48662Down-0.0777999067

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.