HCSGD entry for HHEX

1. General information

Official gene symbolHHEX
Entrez ID3087
Gene full namehematopoietically expressed homeobox
Other gene symbolsHEX HMPH HOX11L-PEN PRH PRHX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002573Myeloid leukocyte differentiationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006406MRNA export from nucleusIDAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008190Eukaryotic initiation factor 4E bindingIDAmolecular_function
GO:0008283Cell proliferationIDAbiological_process
GO:0008301DNA binding, bendingIDAmolecular_function
GO:0009611Response to woundingIEAbiological_process
GO:0009952Anterior/posterior pattern specificationISSbiological_process
GO:0010621Negative regulation of transcription by transcription factor localizationICbiological_process
GO:0010944Negative regulation of transcription by competitive promoter bindingTASbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016525Negative regulation of angiogenesisIEA ISSbiological_process
GO:0016973Poly(A)+ mRNA export from nucleusIMPbiological_process
GO:0017025TBP-class protein bindingTASmolecular_function
GO:0022027Interkinetic nuclear migrationIEAbiological_process
GO:0030154Cell differentiationICbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIEA ISSbiological_process
GO:0030183B cell differentiationIEA ISSbiological_process
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0030948Negative regulation of vascular endothelial growth factor receptor signaling pathwayIEA ISSbiological_process
GO:0031016Pancreas developmentIEAbiological_process
GO:0032993Protein-DNA complexIDAcellular_component
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0035050Embryonic heart tube developmentIEAbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDA TASmolecular_function
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048853Forebrain morphogenesisIEAbiological_process
GO:0060431Primary lung bud formationIEAbiological_process
GO:0061009Common bile duct developmentIEAbiological_process
GO:0061010Gall bladder developmentIEAbiological_process
GO:0061011Hepatic duct developmentIEAbiological_process
GO:0061017Hepatoblast differentiationIEAbiological_process
GO:0070365Hepatocyte differentiationIEAbiological_process
GO:0070491Repressing transcription factor bindingIDAmolecular_function
GO:0071103DNA conformation changeIDAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0090009Primitive streak formationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78874686750.00688344670.99999024730.1653088342

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0954575419
GSE13712_SHEARUp0.0644126254
GSE13712_STATICDown-0.1363708124
GSE19018Down-0.4854562572
GSE19899_A1Down-1.4608138481
GSE19899_A2Down-2.6668514457
PubMed_21979375_A1Down-2.4900665346
PubMed_21979375_A2Down-3.2232734652
GSE35957Down-0.4106450104
GSE36640Up0.8747719385
GSE54402Up0.0909362830
GSE9593Down-0.1735350930
GSE43922Down-0.3871761884
GSE24585Down-0.2719817265
GSE37065Up0.0050230142
GSE28863_A1Down-0.1699693574
GSE28863_A2Down-0.0588729726
GSE28863_A3Up0.2654807860
GSE28863_A4Up0.0289571787
GSE48662Down-0.4426040033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-130b-3pMIMAT0000691MIRT020132SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031099SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.