HCSGD entry for HBG2
1. General information
| Official gene symbol | HBG2 |
|---|---|
| Entrez ID | 3048 |
| Gene full name | hemoglobin, gamma G |
| Other gene symbols | TNCY |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005344 | Oxygen transporter activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005833 | Hemoglobin complex | IEA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0019825 | Oxygen binding | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8945683523 | 0.7309203716 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0475157907 |
| GSE28863_A2 | Down | -0.2558369409 |
| GSE28863_A3 | Up | 0.2304980623 |
| GSE28863_A4 | Down | -0.0227618197 |
| GSE48662 | Up | 0.0297859461 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23889086 | Membrane peroxidation and methemoglobin formation are both necessary for band 3 clustering: mechanistic insights into human erythrocyte senescence |
| 23889086 | Here we show that while neither membrane peroxidation nor methemoglobin (MetHb) formation on their own can induce band 3 clustering in the human erythrocytes, they can do so when acting in combination |
| 10593595 | Incubation of rat erythrocytes with the hydroxylated metabolites of aniline and dapsone (4-4'-diaminodiphenylsulfone), phenylhydroxylamine and dapsone hydroxylamine, respectively, induced marked release of iron and methemoglobin formation |
| 10593595 | On the contrary, no release of iron nor methemoglobin formation was seen when the erythrocytes were incubated with the parent compounds (aniline and dapsone) |
| 10593595 | The acute intoxication of rats with aniline or dapsone induced a marked increase in the erythrocyte content of free iron and methemoglobin, indicating that the xenobiotics are effective only after biotransformation to toxic metabolites in vivo |
| 8960777 | Oxidative stress appears to be responsible for the generation of senescent cell antigen on erythrocytes, to which anti-band 3 antibodies bind, since erythrocytes oxidized in vitro bind anti-band 3 IgG, and various oxidative modifications are observed in senescent erythrocytes as well as the erythrocytes with abnormal hemoglobin |
| 8679546 | Nitrite treatment of intact cells produced almost complete conversion to methemoglobin, but no detectable lipid extraction |
| 7827135 | Pretreatment of young cells with (a) cobalt, which blocks Ca2+ influx through calcium channels, or (b) carbon monoxide, which prevents methemoglobin formation, inhibited the peroxide-induced increase in ionic intracellular calcium |
| 8679516 | In humans, red cell oxidation processes, involving methemoglobin formation, have been correlated with cellular aging |
| 8679516 | Reduced glutathione levels (GSH) and methemoglobin were higher in chicken and ostrich cells than in human cells |
| 8679516 | Ostrich cells were more sensitive to hydrogen peroxide when hemoglobin oxidation was involved; BHP exposure affected GSH depletion and methemoglobin production in ostrich cells more than in the others |
| 2014146 | This oxidation product was not methemoglobin but a trivalent, high-spin iron compound |
| 1805603 | Selective binding of met-hemoglobin to erythrocytic membrane: a possible involvement in red blood cell aging |
| 3619637 | Incubating isolated erythrocytes in phosphate buffered saline supplied with sufficient glucose (20 mM) for several days resulted in methemoglobin formation and decrease in glycolytic and antioxidant enzyme activities |
| 3012219 | Reduced glutathione (GSH), GSH stability and glucose-6-phosphate dehydrogenase (G6PD) activity in fractionated red cells decreased with age, while oxidized glutathione (GSSG) and methemoglobin (MetHb) increased with age |
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