HCSGD entry for GRK4

1. General information

Official gene symbolGRK4
Entrez ID2868
Gene full nameG protein-coupled receptor kinase 4
Other gene symbolsGPRK2L GPRK4 GRK4a IT11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayTASbiological_process
GO:0030425DendriteIEAcellular_component
GO:0031623Receptor internalizationIDAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0050254Rhodopsin kinase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19643918160.95239776600.85774314861.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0967886027
GSE13712_SHEARUp0.0121394977
GSE13712_STATICUp0.3480901548
GSE19018Down-0.0330854168
GSE19899_A1Up0.1313614698
GSE19899_A2Up0.3304630605
PubMed_21979375_A1Up0.5991294769
PubMed_21979375_A2Up0.4986945805
GSE35957Up0.1273440444
GSE36640Up0.5193543239
GSE54402Up0.0103978202
GSE9593Up0.1284137074
GSE43922Up0.0188496447
GSE24585Up0.1015595197
GSE37065Down-0.1032037283
GSE28863_A1Down-0.1710899355
GSE28863_A2Down-0.0409870730
GSE28863_A3Down-0.1142078455
GSE28863_A4Down-0.0053717635
GSE48662Up0.2291776339

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.