HCSGD entry for GRK4

1. General information

Official gene symbolGRK4
Entrez ID2868
Gene full nameG protein-coupled receptor kinase 4
Other gene symbolsGPRK2L GPRK4 GRK4a IT11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayTASbiological_process
GO:0030425DendriteIEAcellular_component
GO:0031623Receptor internalizationIDAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0050254Rhodopsin kinase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19643918160.95239776600.85774314861.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0967886027
GSE13712_SHEARUp0.0121394977
GSE13712_STATICUp0.3480901548
GSE19018Down-0.0330854168
GSE19899_A1Up0.1313614698
GSE19899_A2Up0.3304630605
PubMed_21979375_A1Up0.5991294769
PubMed_21979375_A2Up0.4986945805
GSE35957Up0.1273440444
GSE36640Up0.5193543239
GSE54402Up0.0103978202
GSE9593Up0.1284137074
GSE43922Up0.0188496447
GSE24585Up0.1015595197
GSE37065Down-0.1032037283
GSE28863_A1Down-0.1710899355
GSE28863_A2Down-0.0409870730
GSE28863_A3Down-0.1142078455
GSE28863_A4Down-0.0053717635
GSE48662Up0.2291776339

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.