HCSGD entry for CXCR3

1. General information

Official gene symbolCXCR3
Entrez ID2833
Gene full namechemokine (C-X-C motif) receptor 3
Other gene symbolsCD182 CD183 CKR-L2 CMKAR3 GPR9 IP10-R Mig-R MigR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0002685Regulation of leukocyte migrationIEAbiological_process
GO:0004872Receptor activityIDAmolecular_function
GO:0004950Chemokine receptor activityTASmolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010818T cell chemotaxisIEAbiological_process
GO:0016494C-X-C chemokine receptor activityIEAmolecular_function
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019722Calcium-mediated signalingIEAbiological_process
GO:0019956Chemokine bindingIPImolecular_function
GO:0019958C-X-C chemokine bindingIDAmolecular_function
GO:0030816Positive regulation of cAMP metabolic processIDAbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050921Positive regulation of chemotaxisIDAbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIMPbiological_process
GO:0071954Chemokine (C-C motif) ligand 11 productionIDAbiological_process
GO:1900118Negative regulation of execution phase of apoptosisIDAbiological_process
GO:1900119Positive regulation of execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84909133770.72825149500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0858768159
GSE13712_SHEARUp0.0844976779
GSE13712_STATICDown-0.0587174652
GSE19018Up0.1585150835
GSE19899_A1Down-0.0167727132
GSE19899_A2Up0.1313043492
PubMed_21979375_A1Down-0.0080818043
PubMed_21979375_A2Down-0.0840824625
GSE35957Up0.0139079284
GSE36640Down-0.0162681250
GSE54402Down-0.0867660694
GSE9593Down-0.0415431230
GSE43922Up0.0539166364
GSE24585Down-0.0005253379
GSE37065Up0.0144335868
GSE28863_A1Down-0.0919133149
GSE28863_A2Up0.2241333460
GSE28863_A3Up0.1465333282
GSE28863_A4Down-0.0134413802
GSE48662Down-0.2905031549

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16821141In inflamed portal tracts of PBC, CD4+ T cells of Th1 type expressing IFN-gamma or CXCR3 are aggregated and more commonly detected around injured bile ducts than Th2-type CD4+ T cells expressing IL-4 or CCR4, indicating that Th1-dominant cellular immunity plays a more-prominent role in recruitment of memory T-cell subsets in PBC and may be responsible for the progressive bile duct damage
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