HCSGD entry for CXCR3

1. General information

Official gene symbolCXCR3
Entrez ID2833
Gene full namechemokine (C-X-C motif) receptor 3
Other gene symbolsCD182 CD183 CKR-L2 CMKAR3 GPR9 IP10-R Mig-R MigR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0002685Regulation of leukocyte migrationIEAbiological_process
GO:0004872Receptor activityIDAmolecular_function
GO:0004950Chemokine receptor activityTASmolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010818T cell chemotaxisIEAbiological_process
GO:0016494C-X-C chemokine receptor activityIEAmolecular_function
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019722Calcium-mediated signalingIEAbiological_process
GO:0019956Chemokine bindingIPImolecular_function
GO:0019958C-X-C chemokine bindingIDAmolecular_function
GO:0030816Positive regulation of cAMP metabolic processIDAbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050921Positive regulation of chemotaxisIDAbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIMPbiological_process
GO:0071954Chemokine (C-C motif) ligand 11 productionIDAbiological_process
GO:1900118Negative regulation of execution phase of apoptosisIDAbiological_process
GO:1900119Positive regulation of execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84909133770.72825149500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0858768159
GSE13712_SHEARUp0.0844976779
GSE13712_STATICDown-0.0587174652
GSE19018Up0.1585150835
GSE19899_A1Down-0.0167727132
GSE19899_A2Up0.1313043492
PubMed_21979375_A1Down-0.0080818043
PubMed_21979375_A2Down-0.0840824625
GSE35957Up0.0139079284
GSE36640Down-0.0162681250
GSE54402Down-0.0867660694
GSE9593Down-0.0415431230
GSE43922Up0.0539166364
GSE24585Down-0.0005253379
GSE37065Up0.0144335868
GSE28863_A1Down-0.0919133149
GSE28863_A2Up0.2241333460
GSE28863_A3Up0.1465333282
GSE28863_A4Down-0.0134413802
GSE48662Down-0.2905031549

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16821141In inflamed portal tracts of PBC, CD4+ T cells of Th1 type expressing IFN-gamma or CXCR3 are aggregated and more commonly detected around injured bile ducts than Th2-type CD4+ T cells expressing IL-4 or CCR4, indicating that Th1-dominant cellular immunity plays a more-prominent role in recruitment of memory T-cell subsets in PBC and may be responsible for the progressive bile duct damage
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