HCSGD entry for GNAO1

1. General information

Official gene symbolGNAO1
Entrez ID2775
Gene full nameguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Other gene symbolsG-ALPHA-o GNAO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIBA IEAmolecular_function
GO:0004871Signal transducer activityIBA IEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005834Heterotrimeric G-protein complexIBAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIBA IEAbiological_process
GO:0007212Dopamine receptor signaling pathwayIBA IEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008016Regulation of heart contractionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019001Guanyl nucleotide bindingIEAmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0031175Neuron projection developmentIEAbiological_process
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031821G-protein coupled serotonin receptor bindingIBA IEAmolecular_function
GO:0031852Mu-type opioid receptor bindingIEAmolecular_function
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0034097Response to cytokineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043278Response to morphineIEAbiological_process
GO:0043547Positive regulation of GTPase activityIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051430Corticotropin-releasing hormone receptor 1 bindingIEAmolecular_function
GO:0051926Negative regulation of calcium ion transportIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75107346230.85324084950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0027392791
GSE13712_SHEARUp0.0195800208
GSE13712_STATICDown-0.0988472530
GSE19018Up0.0033570754
GSE19899_A1Up0.0623854652
GSE19899_A2Up0.1207034704
PubMed_21979375_A1Up0.0996286242
PubMed_21979375_A2Down-0.0140285498
GSE35957Up0.2106901412
GSE36640Down-0.0620312884
GSE54402Down-0.0011857025
GSE9593Up0.0468083050
GSE43922Up0.0233394672
GSE24585Up0.0037577110
GSE37065Down-0.1487468879
GSE28863_A1Down-0.0826362778
GSE28863_A2Down-0.1087945484
GSE28863_A3Up0.1927334369
GSE28863_A4Up0.0407932357
GSE48662Up0.3044018011

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23984917The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma
23984917The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR)
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