HCSGD entry for GNAO1

1. General information

Official gene symbolGNAO1
Entrez ID2775
Gene full nameguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Other gene symbolsG-ALPHA-o GNAO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIBA IEAmolecular_function
GO:0004871Signal transducer activityIBA IEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005834Heterotrimeric G-protein complexIBAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIBA IEAbiological_process
GO:0007212Dopamine receptor signaling pathwayIBA IEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008016Regulation of heart contractionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019001Guanyl nucleotide bindingIEAmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0031175Neuron projection developmentIEAbiological_process
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031821G-protein coupled serotonin receptor bindingIBA IEAmolecular_function
GO:0031852Mu-type opioid receptor bindingIEAmolecular_function
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0034097Response to cytokineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043278Response to morphineIEAbiological_process
GO:0043547Positive regulation of GTPase activityIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051430Corticotropin-releasing hormone receptor 1 bindingIEAmolecular_function
GO:0051926Negative regulation of calcium ion transportIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75107346230.85324084950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0027392791
GSE13712_SHEARUp0.0195800208
GSE13712_STATICDown-0.0988472530
GSE19018Up0.0033570754
GSE19899_A1Up0.0623854652
GSE19899_A2Up0.1207034704
PubMed_21979375_A1Up0.0996286242
PubMed_21979375_A2Down-0.0140285498
GSE35957Up0.2106901412
GSE36640Down-0.0620312884
GSE54402Down-0.0011857025
GSE9593Up0.0468083050
GSE43922Up0.0233394672
GSE24585Up0.0037577110
GSE37065Down-0.1487468879
GSE28863_A1Down-0.0826362778
GSE28863_A2Down-0.1087945484
GSE28863_A3Up0.1927334369
GSE28863_A4Up0.0407932357
GSE48662Up0.3044018011

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23984917The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma
23984917The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR)
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