HCSGD entry for GNAI1

1. General information

Official gene symbolGNAI1
Entrez ID2770
Gene full nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Other gene symbolsGi
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIBA IEA RCA TASmolecular_function
GO:0004871Signal transducer activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEA ISSmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005834Heterotrimeric G-protein complexIBAcellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0006906Vesicle fusionIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0019001Guanyl nucleotide bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031821G-protein coupled serotonin receptor bindingIBA IEAmolecular_function
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0042588Zymogen granuleIEAcellular_component
GO:0043434Response to peptide hormoneISSbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051301Cell divisionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08051523880.63902955810.59798013541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2450940971
GSE13712_SHEARDown-0.1326912879
GSE13712_STATICUp0.2540664944
GSE19018Down-0.1624575633
GSE19899_A1Up0.0994187163
GSE19899_A2Up0.2028015509
PubMed_21979375_A1Up0.5463375692
PubMed_21979375_A2Up0.6454368933
GSE35957Up0.5525953939
GSE36640Up0.8497581354
GSE54402Down-0.3341934318
GSE9593Up0.1829935782
GSE43922Up0.4499600951
GSE24585Up0.2556074968
GSE37065Up0.0800819292
GSE28863_A1Down-0.2606318411
GSE28863_A2Up0.1882454775
GSE28863_A3Down-0.5513596940
GSE28863_A4Down-0.2323843216
GSE48662Down-0.2871247091

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Guanosine-5'-DiphosphateDB04315 EXPT01573
Tetrafluoroaluminate IonDB04444 EXPT00497

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT021108SequencingFunctional MTI (Weak)20371350
hsa-miR-1MIMAT0000416MIRT023552Proteomics;MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.