HCSGD entry for GNAI1

1. General information

Official gene symbolGNAI1
Entrez ID2770
Gene full nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Other gene symbolsGi
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIBA IEA RCA TASmolecular_function
GO:0004871Signal transducer activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEA ISSmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005834Heterotrimeric G-protein complexIBAcellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0006906Vesicle fusionIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0019001Guanyl nucleotide bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031821G-protein coupled serotonin receptor bindingIBA IEAmolecular_function
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0042588Zymogen granuleIEAcellular_component
GO:0043434Response to peptide hormoneISSbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051301Cell divisionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08051523880.63902955810.59798013541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2450940971
GSE13712_SHEARDown-0.1326912879
GSE13712_STATICUp0.2540664944
GSE19018Down-0.1624575633
GSE19899_A1Up0.0994187163
GSE19899_A2Up0.2028015509
PubMed_21979375_A1Up0.5463375692
PubMed_21979375_A2Up0.6454368933
GSE35957Up0.5525953939
GSE36640Up0.8497581354
GSE54402Down-0.3341934318
GSE9593Up0.1829935782
GSE43922Up0.4499600951
GSE24585Up0.2556074968
GSE37065Up0.0800819292
GSE28863_A1Down-0.2606318411
GSE28863_A2Up0.1882454775
GSE28863_A3Down-0.5513596940
GSE28863_A4Down-0.2323843216
GSE48662Down-0.2871247091

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Guanosine-5'-DiphosphateDB04315 EXPT01573
Tetrafluoroaluminate IonDB04444 EXPT00497

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT021108SequencingFunctional MTI (Weak)20371350
hsa-miR-1MIMAT0000416MIRT023552Proteomics;MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.