HCSGD entry for GNA12
1. General information
| Official gene symbol | GNA12 |
|---|---|
| Entrez ID | 2768 |
| Gene full name | guanine nucleotide binding protein (G protein) alpha 12 |
| Other gene symbols | NNX3 RMP gep |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IEA | molecular_function |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003924 | GTPase activity | IBA IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005834 | Heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA TAS | biological_process |
| GO:0007188 | Adenylate cyclase-modulating G-protein coupled receptor signaling pathway | IBA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007266 | Rho protein signal transduction | IBA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008360 | Regulation of cell shape | IEA | biological_process |
| GO:0010762 | Regulation of fibroblast migration | ISS | biological_process |
| GO:0019001 | Guanyl nucleotide binding | IEA | molecular_function |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IBA | cellular_component |
| GO:0031526 | Brush border membrane | IBA | cellular_component |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA IEA | molecular_function |
| GO:0031752 | D5 dopamine receptor binding | IBA | molecular_function |
| GO:0032006 | Regulation of TOR signaling | IMP | biological_process |
| GO:0032434 | Regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042733 | Embryonic digit morphogenesis | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9355394248 | 0.1217233464 | 0.9999902473 | 0.6700246028 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2591875129 |
| GSE13712_SHEAR | Down | -0.6045301584 |
| GSE13712_STATIC | Down | -0.3013884008 |
| GSE19018 | Down | -0.2193521577 |
| GSE19899_A1 | Down | -0.3280606757 |
| GSE19899_A2 | Up | 0.0147221136 |
| PubMed_21979375_A1 | Down | -0.4050631156 |
| PubMed_21979375_A2 | Up | 0.0957261756 |
| GSE35957 | Down | -0.2364497353 |
| GSE36640 | Down | -0.0882262445 |
| GSE54402 | Down | -0.0079180991 |
| GSE9593 | Up | 0.1842768232 |
| GSE43922 | Down | -0.0338175922 |
| GSE24585 | Down | -0.0124043486 |
| GSE37065 | Down | -0.3184984776 |
| GSE28863_A1 | Up | 0.2481723125 |
| GSE28863_A2 | Up | 0.3901286798 |
| GSE28863_A3 | Up | 0.0414375285 |
| GSE28863_A4 | Down | -0.0766166007 |
| GSE48662 | Up | 0.1686041155 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023075 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027790 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028098 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046311 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
