HCSGD entry for GNA12

1. General information

Official gene symbolGNA12
Entrez ID2768
Gene full nameguanine nucleotide binding protein (G protein) alpha 12
Other gene symbolsNNX3 RMP gep
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001664G-protein coupled receptor bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003924GTPase activityIBA IEAmolecular_function
GO:0004871Signal transducer activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005834Heterotrimeric G-protein complexIBAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEA TASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIBAbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007266Rho protein signal transductionIBAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0010762Regulation of fibroblast migrationISSbiological_process
GO:0019001Guanyl nucleotide bindingIEAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIBAcellular_component
GO:0031526Brush border membraneIBAcellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIBA IEAmolecular_function
GO:0031752D5 dopamine receptor bindingIBAmolecular_function
GO:0032006Regulation of TOR signalingIMPbiological_process
GO:0032434Regulation of proteasomal ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93553942480.12172334640.99999024730.6700246028

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2591875129
GSE13712_SHEARDown-0.6045301584
GSE13712_STATICDown-0.3013884008
GSE19018Down-0.2193521577
GSE19899_A1Down-0.3280606757
GSE19899_A2Up0.0147221136
PubMed_21979375_A1Down-0.4050631156
PubMed_21979375_A2Up0.0957261756
GSE35957Down-0.2364497353
GSE36640Down-0.0882262445
GSE54402Down-0.0079180991
GSE9593Up0.1842768232
GSE43922Down-0.0338175922
GSE24585Down-0.0124043486
GSE37065Down-0.3184984776
GSE28863_A1Up0.2481723125
GSE28863_A2Up0.3901286798
GSE28863_A3Up0.0414375285
GSE28863_A4Down-0.0766166007
GSE48662Up0.1686041155

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023075MicroarrayFunctional MTI (Weak)18668037
hsa-miR-98-5pMIMAT0000096MIRT027790MicroarrayFunctional MTI (Weak)19088304
hsa-miR-93-5pMIMAT0000093MIRT028098SequencingFunctional MTI (Weak)20371350
hsa-miR-149-5pMIMAT0000450MIRT045616CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046311CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.