HCSGD entry for GLUD1

1. General information

Official gene symbolGLUD1
Entrez ID2746
Gene full nameglutamate dehydrogenase 1
Other gene symbolsGDH GDH1 GLUD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004352Glutamate dehydrogenase (NAD+) activityIDAmolecular_function
GO:0004353Glutamate dehydrogenase [NAD(P)+] activityEXP IDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006537Glutamate biosynthetic processIDAbiological_process
GO:0006538Glutamate catabolic processIDAbiological_process
GO:0006541Glutamine metabolic processISSbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0016639Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptorIEAmolecular_function
GO:0032024Positive regulation of insulin secretionIMPbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042802Identical protein bindingTASmolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0070403NAD+ bindingIDAmolecular_function
GO:0070728Leucine bindingIDAmolecular_function
GO:0072350Tricarboxylic acid metabolic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48867311650.17985933670.99999024730.8210332293

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3655049581
GSE13712_SHEARUp0.3293313405
GSE13712_STATICUp0.0187797366
GSE19018Up0.2419820778
GSE19899_A1Down-0.1383424985
GSE19899_A2Down-0.3044251554
PubMed_21979375_A1Up0.2334083424
PubMed_21979375_A2Down-0.1166051364
GSE35957Down-0.2388650605
GSE36640Up0.1297534761
GSE54402Down-0.1846617932
GSE9593Up0.2716355658
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.4908310343
GSE28863_A2Up0.3348943667
GSE28863_A3Down-0.6816245212
GSE28863_A4Down-0.1240767609
GSE48662Down-0.2081727129

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Guanosine-5'-TriphosphateDB04137 EXPT01660

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038802CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041407CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045359CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048701CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.