HCSGD entry for GLUD1

1. General information

Official gene symbolGLUD1
Entrez ID2746
Gene full nameglutamate dehydrogenase 1
Other gene symbolsGDH GDH1 GLUD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004352Glutamate dehydrogenase (NAD+) activityIDAmolecular_function
GO:0004353Glutamate dehydrogenase [NAD(P)+] activityEXP IDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006537Glutamate biosynthetic processIDAbiological_process
GO:0006538Glutamate catabolic processIDAbiological_process
GO:0006541Glutamine metabolic processISSbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0016639Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptorIEAmolecular_function
GO:0032024Positive regulation of insulin secretionIMPbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042802Identical protein bindingTASmolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0070403NAD+ bindingIDAmolecular_function
GO:0070728Leucine bindingIDAmolecular_function
GO:0072350Tricarboxylic acid metabolic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48867311650.17985933670.99999024730.8210332293

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3655049581
GSE13712_SHEARUp0.3293313405
GSE13712_STATICUp0.0187797366
GSE19018Up0.2419820778
GSE19899_A1Down-0.1383424985
GSE19899_A2Down-0.3044251554
PubMed_21979375_A1Up0.2334083424
PubMed_21979375_A2Down-0.1166051364
GSE35957Down-0.2388650605
GSE36640Up0.1297534761
GSE54402Down-0.1846617932
GSE9593Up0.2716355658
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.4908310343
GSE28863_A2Up0.3348943667
GSE28863_A3Down-0.6816245212
GSE28863_A4Down-0.1240767609
GSE48662Down-0.2081727129

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Guanosine-5'-TriphosphateDB04137 EXPT01660

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038802CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041407CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045359CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048701CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.