HCSGD entry for GLS
1. General information
| Official gene symbol | GLS |
|---|---|
| Entrez ID | 2744 |
| Gene full name | glutaminase |
| Other gene symbols | AAD20 GAC GAM GLS1 KGA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001967 | Suckling behavior | IEA | biological_process |
| GO:0002087 | Regulation of respiratory gaseous exchange by neurological system process | IEA | biological_process |
| GO:0004359 | Glutaminase activity | IDA IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA NAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006537 | Glutamate biosynthetic process | IDA IEA TAS | biological_process |
| GO:0006541 | Glutamine metabolic process | IEA | biological_process |
| GO:0006543 | Glutamine catabolic process | IDA IEA NAS | biological_process |
| GO:0007268 | Synaptic transmission | IEA TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0014047 | Glutamate secretion | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051289 | Protein homotetramerization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0139585160 | 0.1242898066 | 0.2937043965 | 0.6773151139 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3682348169 |
| GSE13712_SHEAR | Up | 0.1166844877 |
| GSE13712_STATIC | Up | 0.0019455590 |
| GSE19018 | Down | -0.3928073350 |
| GSE19899_A1 | Up | 0.4512327866 |
| GSE19899_A2 | Up | 0.9955924319 |
| PubMed_21979375_A1 | Up | 0.3919737697 |
| PubMed_21979375_A2 | Up | 0.9600062505 |
| GSE35957 | Up | 0.9914733009 |
| GSE36640 | Up | 1.5651191619 |
| GSE54402 | Up | 0.8619782794 |
| GSE9593 | Up | 0.3242578276 |
| GSE43922 | Up | 0.3608163529 |
| GSE24585 | Down | -0.1279639037 |
| GSE37065 | Down | -0.5876638413 |
| GSE28863_A1 | Down | -0.3446140515 |
| GSE28863_A2 | Up | 0.2196559384 |
| GSE28863_A3 | Down | -0.6939378023 |
| GSE28863_A4 | Down | -0.6546381654 |
| GSE48662 | Up | 0.3395956566 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018403 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025883 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025883 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26907686 | Additionally, we found that glutaminase 2 (GLS2), a modulator of p73-dependent antioxidant defense, is also involved in PCBP2-regulated ROS production |
| 18317946 | Premature senescence of human endothelial cells induced by inhibition of glutaminase |
| 18317946 | On the other hand, glutamine consumption was increased in senescent HUVEC and inhibition of glutaminolysis by DON, a specific inhibitor of glutaminase, led to a significant reduction in the proliferative capacity of both early passage and late passage cells |
| 18317946 | Moreover, inhibition of glutaminase activity induced a senescent-like phenotype in young HUVEC within two passages |
| 2864350 | This suggests that the increased ammonia production presumably resulting from glutaminase activity of the observed increase of transpeptidase may profoundly affect certain cellular functions |
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