HCSGD entry for GLS

1. General information

Official gene symbolGLS
Entrez ID2744
Gene full nameglutaminase
Other gene symbolsAAD20 GAC GAM GLS1 KGA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001967Suckling behaviorIEAbiological_process
GO:0002087Regulation of respiratory gaseous exchange by neurological system processIEAbiological_process
GO:0004359Glutaminase activityIDA IEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDA NAScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005829CytosolIEAcellular_component
GO:0006537Glutamate biosynthetic processIDA IEA TASbiological_process
GO:0006541Glutamine metabolic processIEAbiological_process
GO:0006543Glutamine catabolic processIDA IEA NASbiological_process
GO:0007268Synaptic transmissionIEA TASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0014047Glutamate secretionTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051289Protein homotetramerizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01395851600.12428980660.29370439650.6773151139

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3682348169
GSE13712_SHEARUp0.1166844877
GSE13712_STATICUp0.0019455590
GSE19018Down-0.3928073350
GSE19899_A1Up0.4512327866
GSE19899_A2Up0.9955924319
PubMed_21979375_A1Up0.3919737697
PubMed_21979375_A2Up0.9600062505
GSE35957Up0.9914733009
GSE36640Up1.5651191619
GSE54402Up0.8619782794
GSE9593Up0.3242578276
GSE43922Up0.3608163529
GSE24585Down-0.1279639037
GSE37065Down-0.5876638413
GSE28863_A1Down-0.3446140515
GSE28863_A2Up0.2196559384
GSE28863_A3Down-0.6939378023
GSE28863_A4Down-0.6546381654
GSE48662Up0.3395956566

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018403MicroarrayFunctional MTI (Weak)18185580
hsa-miR-7-5pMIMAT0000252MIRT025883MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025883MicroarrayFunctional MTI (Weak)19073608
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26907686Additionally, we found that glutaminase 2 (GLS2), a modulator of p73-dependent antioxidant defense, is also involved in PCBP2-regulated ROS production
18317946Premature senescence of human endothelial cells induced by inhibition of glutaminase
18317946On the other hand, glutamine consumption was increased in senescent HUVEC and inhibition of glutaminolysis by DON, a specific inhibitor of glutaminase, led to a significant reduction in the proliferative capacity of both early passage and late passage cells
18317946Moreover, inhibition of glutaminase activity induced a senescent-like phenotype in young HUVEC within two passages
2864350This suggests that the increased ammonia production presumably resulting from glutaminase activity of the observed increase of transpeptidase may profoundly affect certain cellular functions
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