HCSGD entry for GLI2

1. General information

Official gene symbolGLI2
Entrez ID2736
Gene full nameGLI family zinc finger 2
Other gene symbolsHPE9 THP1 THP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0001501Skeletal system developmentISSbiological_process
GO:0001649Osteoblast differentiationIDAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001822Kidney developmentIEA ISSbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0002076Osteoblast developmentIEA ISSbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0007224Smoothened signaling pathwayIDAbiological_process
GO:0007389Pattern specification processISSbiological_process
GO:0007411Axon guidanceIEA ISSbiological_process
GO:0007418Ventral midline developmentISSbiological_process
GO:0007442Hindgut morphogenesisIEA ISSbiological_process
GO:0007507Heart developmentIEA ISSbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008283Cell proliferationIDA IEAbiological_process
GO:0008589Regulation of smoothened signaling pathwayIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009913Epidermal cell differentiationIDAbiological_process
GO:0009954Proximal/distal pattern formationIEA ISSbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016607Nuclear speckIEAcellular_component
GO:0021508Floor plate formationIEA ISSbiological_process
GO:0021513Spinal cord dorsal/ventral patterningISSbiological_process
GO:0021517Ventral spinal cord developmentISSbiological_process
GO:0021696Cerebellar cortex morphogenesisIEA ISSbiological_process
GO:0021775Smoothened signaling pathway involved in ventral spinal cord interneuron specificationIEA ISSbiological_process
GO:0021776Smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationIEAbiological_process
GO:0021938Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationIEAbiological_process
GO:0021965Spinal cord ventral commissure morphogenesisIEA ISSbiological_process
GO:0021983Pituitary gland developmentIEA ISSbiological_process
GO:0030324Lung developmentIEA ISSbiological_process
GO:0030879Mammary gland developmentISSbiological_process
GO:0030902Hindbrain developmentISSbiological_process
GO:0031512Motile primary ciliumIEAcellular_component
GO:0032331Negative regulation of chondrocyte differentiationIEAbiological_process
GO:0033089Positive regulation of T cell differentiation in thymusISSbiological_process
GO:0035295Tube developmentISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEA ISSbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048566Embryonic digestive tract developmentIEA ISSbiological_process
GO:0048589Developmental growthIEA ISSbiological_process
GO:0048666Neuron developmentISSbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEA ISSbiological_process
GO:0060032Notochord regressionIEAbiological_process
GO:0060322Head developmentIEAbiological_process
GO:0060513Prostatic bud formationIEAbiological_process
GO:0060603Mammary gland duct morphogenesisIEAbiological_process
GO:0060831Smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0090103Cochlea morphogenesisIEAbiological_process
GO:2001141Regulation of RNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99705059080.00747571900.99999024730.1729640598

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3584149388
GSE13712_SHEARDown-0.1374349939
GSE13712_STATICDown-0.0827152599
GSE19018Down-0.2770651357
GSE19899_A1Down-0.5586437773
GSE19899_A2Down-1.2072909772
PubMed_21979375_A1Down-1.2276960818
PubMed_21979375_A2Down-1.0294353523
GSE35957Down-0.3123854567
GSE36640Down-0.2288074951
GSE54402Down-0.2766020575
GSE9593Down-0.2005882777
GSE43922Down-0.6403643217
GSE24585Down-0.1832709702
GSE37065Down-0.1264172469
GSE28863_A1Up0.1436946403
GSE28863_A2Up0.0019283937
GSE28863_A3Up0.0265672734
GSE28863_A4Down-0.1862923271
GSE48662Down-0.1641048332

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023940MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029923MicroarrayFunctional MTI (Weak)19088304
hsa-miR-31-5pMIMAT0000089MIRT049876CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25754218Primary bovine aortic endothelial cells, exposed to the secretome of THP-1 monocyte-derived foam cells, were analysed for the induction of senescence
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